Uropathogenic Escherichia coli (UPEC)-Associated Urinary Tract Infections: The Molecular Basis for Challenges to Effective Treatment

S Whelan, B Lucey, K Finn - Microorganisms, 2023 - mdpi.com
Urinary tract infections (UTIs) are among the most common bacterial infections, especially
among women and older adults, leading to a significant global healthcare cost burden …

Engineering Phages to Fight Multidrug-Resistant Bacteria

H Peng, IA Chen, U Qimron - Chemical Reviews, 2024 - ACS Publications
Facing the global “superbug” crisis due to the emergence and selection for antibiotic
resistance, phages are among the most promising solutions. Fighting multidrug-resistant …

Phage therapy: An alternative treatment modality for MDR bacterial infections

N Pal, P Sharma, M Kumawat, S Singh… - Infectious …, 2024 - Taylor & Francis
The increasing global incidence of multidrug-resistant (MDR) bacterial infections threatens
public health and compromises various aspects of modern medicine. Recognising the …

[HTML][HTML] Development of phage resistance in multidrug-resistant Klebsiella pneumoniae is associated with reduced virulence: a case report of a personalised phage …

J Li, B Yan, B He, L Li, X Zhou, N Wu, Q Wang… - Clinical Microbiology …, 2023 - Elsevier
Objectives Phage-resistant bacteria often emerge rapidly when performing phage therapy.
However, the relationship between the emergence of phage-resistant bacteria and …

Challenges and opportunities of phage therapy for Klebsiella pneumoniae infections

X Kou, X Yang, R Zheng - Applied and Environmental …, 2024 - journals.asm.org
Traditional antibiotics have been effective in many cases. However, the rise in multidrug-
resistant bacteria has diminished their therapeutic efficacy, signaling the dawn of an era …

PhageGE: an interactive web platform for exploratory analysis and visualization of bacteriophage genomes

J Zhao, J Han, YW Lin, Y Zhu, M Aichem… - …, 2024 - academic.oup.com
Background Antimicrobial resistance is a serious threat to global health. Due to the stagnant
antibiotic discovery pipeline, bacteriophages (phages) have been proposed as an …

[HTML][HTML] Phages and phage-borne enzymes as new antibacterial agents

S McCallin, Z Drulis-Kawa, T Ferry, JP Pirnay… - Clinical Microbiology …, 2023 - Elsevier
Background Persistent and resistant infections caused by bacteria are increasing in
numbers and pose a treatment challenge to the medical community and public health …

Phage therapy in lung transplantation: current status and future possibilities

S Aslam - Clinical Infectious Diseases, 2023 - academic.oup.com
Patients with chronic lung disease and lung transplantation have high rates of colonization
and infection from multidrug-resistant (MDR) organisms. This article summarizes the current …

Automating Predictive Phage Therapy Pharmacology

ST Abedon - Antibiotics, 2023 - mdpi.com
Viruses that infect as well as often kill bacteria are called bacteriophages, or phages.
Because of their ability to act bactericidally, phages increasingly are being employed …

Bacteriophage treatment is effective against carbapenem-resistant Klebsiella pneumoniae (KPC) in a neutropenic murine model of gastrointestinal translocation and …

P Zagaliotis, J Michalik-Provasek… - Antimicrobial Agents …, 2024 - journals.asm.org
Carbapenemase-producing Klebsiella pneumoniae (KPC) are globally emerging pathogens
that cause life-threatening infections. Novel treatment alternatives are urgently needed. We …