Autoimmune disorders are characterized as a condition in which the host's immune system
mistakenly attacks itself. These disorders cause the immune system to cause a systemic …

Multiple genetic and environmental factors have been associated with an increased risk for
rheumatoid arthritis (RA). Of these, the strongest associations have been seen with female …

Rheumatoid arthritis (RA) is the most common systemic inflammatory rheumatic disease. It is
associated with significant burden at the patient and societal level. Extensive efforts have …

Chapter summary The prevalence of rheumatoid arthritis (RA) is relatively constant in many
populations, at 0.5–1.0%. However, a high prevalence of RA has been reported in the Pima …

RA is the most common chronic systemic autoimmune disease, with a higher prevalence in
women, suggesting female hormonal factors play a role in the development of the disease …

Objective To explore the contribution of female hormonal factors occurring prior to the onset
of rheumatoid arthritis (RA), such as age at menarche, parity, age at first birth, breast …

ContextPhysiologic changes of pregnancy include insulin resistance, thrombophilia,
immunosuppression, and hypervolemia. These changes may herald the development of …

The Ncf1 gene was recently identified as a strong regulator of severe arthritis in rat. This
finding was surprising, because the disease-promoting allele mediated a lower level of …

There is now a general consensus that RA has a spectrum of disease stages that can begin
many years before the onset of clinical symptoms. It is widely thought that understanding the …

Objective To study the association of cigarette smoking with risk of rheumatoid arthritis (RA),
among 377,481 female health professionals in the Women's Health Cohort Study. Methods …