The study of the cortical control of movement experienced a conceptual shift over recent
decades, as the basic currency of understanding shifted from single-neuron tuning towards …

Since the original demonstration that electrical activity generated by ensembles of cortical
neurons can be employed directly to control a robotic manipulator, research on brain …

Populations of cortical neurons flexibly perform different functions; for the primary motor
cortex (M1) this means a rich repertoire of motor behaviors. We investigate the flexibility of …

Most theories of motor cortex have assumed that neural activity represents movement
parameters. This view derives from what is known about primary visual cortex, where neural …

Primate motor cortex projects to spinal interneurons and motoneurons, suggesting that
motor cortex activity may be dominated by muscle-like commands. Observations during …

Rapid execution of motor sequences is believed to depend on fusing movement elements
into cohesive units that are executed holistically. We sought to determine the contribution of …

Representational models specify how activity patterns in populations of neurons (or, more
generally, in multivariate brain-activity measurements) relate to sensory stimuli, motor …

The loss of a limb or paralysis resulting from spinal cord injury has devastating
consequences on quality of life. One approach to restoring lost sensory and motor abilities in …

The motor cortices are active during both movement and movement preparation. A common
assumption is that preparatory activity constitutes a subthreshold form of movement activity …

We used retrograde transneuronal transport of rabies virus from single muscles of rhesus
monkeys to identify cortico-motoneuronal (CM) cells in the primary motor cortex (M1) that …