Polymicrobial communities in periodontal disease: Their quasi‐organismal nature and dialogue with the host

G Hajishengallis, RJ Lamont - Periodontology 2000, 2021 - Wiley Online Library
In health, indigenous polymicrobial communities at mucosal surfaces maintain an ecological
balance via both inter‐microbial and host‐microbial interactions that promote their own and …

Roles of Porphyromonas gingivalis and its virulence factors in periodontitis

W Xu, W Zhou, H Wang, S Liang - Advances in protein chemistry and …, 2020 - Elsevier
Periodontitis is an infection-driven inflammatory disease, which is characterized by gingival
inflammation and bone loss. Periodontitis is associated with various systemic diseases …

Periodontitis: from microbial immune subversion to systemic inflammation

G Hajishengallis - Nature reviews immunology, 2015 - nature.com
Periodontitis is a dysbiotic inflammatory disease with an adverse impact on systemic health.
Recent studies have provided insights into the emergence and persistence of dysbiotic oral …

The oral microbiome and the immunobiology of periodontal disease and caries

M Costalonga, MC Herzberg - Immunology letters, 2014 - Elsevier
The composition of the oral microbiome differs from one intraoral site to another, reflecting in
part the host response and immune capacity at each site. By focusing on two major oral …

Polymicrobial synergy and dysbiosis in inflammatory disease

RJ Lamont, G Hajishengallis - Trends in molecular medicine, 2015 - cell.com
Uncontrolled inflammation of the periodontal area may arise when complex microbial
communities transition from a commensal to a pathogenic entity. Communication among …

Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later

G Hajishengallis, JM Korostoff - Periodontology 2000, 2017 - Wiley Online Library
In their classic 1976 paper, Page & Schroeder described the histopathologic events and the
types of myeloid cells and lymphocytes involved in the initiation and progression of …

The inflammophilic character of the periodontitis‐associated microbiota

G Hajishengallis - Molecular oral microbiology, 2014 - Wiley Online Library
In periodontitis, dysbiotic microbial communities exhibit synergistic interactions for enhanced
protection from host defenses, nutrient acquisition, and persistence in an inflammatory …

One-step hydrothermal synthesis of photoluminescent carbon nanodots with selective antibacterial activity against Porphyromonas gingivalis

J Liu, S Lu, Q Tang, K Zhang, W Yu, H Sun, B Yang - Nanoscale, 2017 - pubs.rsc.org
Carbon dots (CDs) with high quantum yield (QY), low toxicity and good biocompatibility are
the major quests of biomedical research. In this paper, we develop a green, simple …

New developments in neutrophil biology and periodontitis

G Hajishengallis - Periodontology 2000, 2020 - Wiley Online Library
Neutrophils have been historically associated with antimicrobial functions in acute infections
but are now appreciated as functionally versatile cells with critical roles in chronic …

Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α‐enolase: Implications for autoimmunity in rheumatoid arthritis

N Wegner, R Wait, A Sroka, S Eick… - Arthritis & …, 2010 - Wiley Online Library
Objective To investigate protein citrullination by the periodontal pathogen Porphyromonas
gingivalis as a potential mechanism for breaking tolerance to citrullinated proteins in …