The Rho GTPases form a subgroup of the Ras superfamily of 20-to 30-kD GTP-binding
proteins that have been shown to regulate a wide spectrum of cellular functions. These …

Publisher Summary The chapter introduces the mitogen-activated protein (MAP) kinase
(MAPK) module. The identification of MAP kinase pathways exemplifies the power of …

Rho GTPases control signal transduction pathways that link cell surface receptors to a
variety of intracellular responses. They are best known as regulators of the actin …

▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …

The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important
pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells …

Rho GTPases control many aspects of cell behavior through the regulation of multiple signal
transduction pathways (Van Aelst and D'Souza-Schorey 1997; Hall 1998). Rho, Rac, and …

When a stimulatory agonist molecule binds at the exterior of the cell membrane, a second
messenger transduces the signal to the interior of the cell. Second messengers can be …

Insulin plays a key role in regulating a wide range of cellular processes. However, until
recently little was known about the signalling pathways that are involved in linking the …

▪ Abstract Members of the Rho family of small Ras-like GTPases—including RhoA,-B, and-C,
Rac1 and-2, and Cdc42—exhibit guanine nucleotide-binding activity and function as …

We describe a protein with the hallmarks of a chemokine, designated CXCL16, that is made
by dendritic cells (DCs) in lymphoid organ T cell zones and by cells in the splenic red pulp …