Tracing the Evolution of Human Immunity Through Ancient DNA
Infections have imposed strong selection pressures throughout human evolution, making the
study of natural selection's effects on immunity genes highly complementary to disease …
study of natural selection's effects on immunity genes highly complementary to disease …
A geometric relationship of F2, F3 and F4-statistics with principal component analysis
Principal component analysis (PCA) and F-statistics sensu Patterson are two of the most
widely used population genetic tools to study human genetic variation. Here, I derive explicit …
widely used population genetic tools to study human genetic variation. Here, I derive explicit …
Applications of X-chromosome short tandem repeats for human identification: a review: applications of X-chromosome short tandem repeats for human identification
The forensic DNA profiling technique has tremendously contributed to forensic human
identification, an important aspect in forensic investigations. In instances whereby …
identification, an important aspect in forensic investigations. In instances whereby …
Colonialism in South Africa leaves a lasting legacy of reduced genetic diversity in Cape buffalo
The iconic Cape buffalo has experienced several documented population declines in recent
history. These declines have been largely attributed to the late 19th century rinderpest …
history. These declines have been largely attributed to the late 19th century rinderpest …
[HTML][HTML] Estimating heritability explained by local ancestry and evaluating stratification bias in admixture map** from summary statistics
The heritability explained by local ancestry markers in an admixed population (h γ 2)
provides crucial insight into the genetic architecture of a complex disease or trait. Estimation …
provides crucial insight into the genetic architecture of a complex disease or trait. Estimation …
Localizing post-admixture adaptive variants with object detection on ancestry-painted chromosomes
Gene flow between previously differentiated populations during the founding of an admixed
or hybrid population has the potential to introduce adaptive alleles into the new population. If …
or hybrid population has the potential to introduce adaptive alleles into the new population. If …
Genome-wide association study of osteoporosis identifies genetic risk and interactions with Dietary Approaches to Stop Hypertension diet and sugar-sweetened …
Osteoporosis (OP) and low bone mass can be debilitating and costly conditions if not acted
on quickly. This disease is also difficult to diagnose as the symptoms develop unnoticed until …
on quickly. This disease is also difficult to diagnose as the symptoms develop unnoticed until …
On the number of genealogical ancestors tracing to the source groups of an admixed population
Members of genetically admixed populations possess ancestry from multiple source groups,
and studies of human genetic admixture frequently estimate ancestry components …
and studies of human genetic admixture frequently estimate ancestry components …
Celebrating 50 years since Lewontin's apportionment of human diversity
1. Introduction '85% of human genetic variation resides within populations'—Richard
Lewontin's result and sound bite, tracing to his 1972 article 'The apportionment of human …
Lewontin's result and sound bite, tracing to his 1972 article 'The apportionment of human …
AncestryGrapher toolkit: Python command-line pipelines to visualize global-and local-ancestry inferences from the RFMIX version 2 software
Admixture is a fundamental process that has shaped levels and patterns of genetic variation
in human populations. RFMIX version 2 (RFMIX2) utilizes a robust modeling approach to …
in human populations. RFMIX version 2 (RFMIX2) utilizes a robust modeling approach to …