Lignin is one of the most abundant renewable resources on earth and is readily produced as
a sidestream during biomass fractioning. So far, these large quantities of lignin have been …

Corynebacterium glutamicum is a major workhorse in industrial biotechnology. For the past
several decades, this soil bacterium has been used to produce the amino acids l-glutamate …

Here, we describe the development of a genetically defined strain of l-lysine hyperproducing
Corynebacterium glutamicum by systems metabolic engineering of the wild type …

Corynebacterium glutamicum, Escherichia coli, and Saccharomyces cerevisiae in particular,
have become established as important industrial workhorses in biotechnology. Recent years …

Pentose phosphate pathway and isocitrate dehydrogenase are generally considered to be
the major sources of the anabolic reductant NADPH. As one of very few microbes …

In many organisms, metabolite interconversion at the phosphoenolpyruvate (PEP)–pyruvate–
oxaloacetate node involves a structurally entangled set of reactions that interconnects the …

Polyethylene terephthalate (PET), the most common synthetic polyester today, is largely
produced from fossil resources, contributing to global warming. Consequently, sustainable …

With a world market of more than four million tons per year, l-amino acids are among the
most important products in industrial biotechnology. The recent years have seen a …

The structurally conserved and ubiquitous pathways of central carbon metabolism provide
building blocks and cofactors for the biosynthesis of cellular macromolecules. The relative …

Re-naturalized quarry lakes are important ecosystems, which support complex communities
of flora and fauna. Microorganisms associated with sediment and water form the lowest …