Chemical ecology of antibiotic production by actinomycetes

A Van der Meij, SF Worsley… - FEMS microbiology …, 2017 - academic.oup.com
Actinomycetes are a diverse family of filamentous bacteria that produce a plethora of natural
products relevant for agriculture, biotechnology and medicine, including the majority of the …

The complex extracellular biology of Streptomyces

KF Chater, S Biró, KJ Lee, T Palmer… - FEMS microbiology …, 2010 - academic.oup.com
Streptomycetes, soil-dwelling mycelial bacteria that form sporulating aerial branches, have
an exceptionally large number of predicted secreted proteins, including many exported via …

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

GP Van Wezel, KJ McDowall - Natural product reports, 2011 - pubs.rsc.org
Covering: up to early 2011 Streptomycetes and other actinobacteria are renowned as a rich
source of natural products of clinical, agricultural and biotechnological value. They are being …

Triggers and cues that activate antibiotic production by actinomycetes

H Zhu, SK Sandiford… - Journal of Industrial …, 2014 - academic.oup.com
Actinomycetes are a rich source of natural products, and these mycelial bacteria produce the
majority of the known antibiotics. The increasing difficulty to find new drugs via high …

Specialised metabolites regulating antibiotic biosynthesis in Streptomyces spp.

G Niu, KF Chater, Y Tian, J Zhang… - FEMS Microbiology …, 2016 - academic.oup.com
Streptomyces bacteria are the major source of antibiotics and other secondary metabolites.
Various environmental and physiological conditions affect the onset and level of production …

Morphogenetic signaling molecules of the streptomycetes

JM Willey, AA Gaskell - Chemical reviews, 2011 - ACS Publications
Selman Waksman's seminal discovery that streptomycin, a natural product produced by
Streptomyces griseus, 1 could be used to treat tuberculosis set the stage for decades of …

Microparticles globally reprogram Streptomyces albus toward accelerated morphogenesis, streamlined carbon core metabolism, and enhanced production of the …

M Kuhl, L Gläser, Y Rebets, C Rückert… - Biotechnology and …, 2020 - Wiley Online Library
Streptomyces spp. are a rich source for natural products with recognized industrial value,
explaining the high interest to improve and streamline the performance of in these microbes …

Superior production of heavy pamamycin derivatives using a bkdR deletion mutant of Streptomyces albus J1074/R2

L Gläser, M Kuhl, J Stegmüller, C Rückert… - Microbial cell …, 2021 - Springer
Background Pamamycins are macrodiolides of polyketide origin which form a family of
differently large homologues with molecular weights between 579 and 663. They offer …

Copper mining in Streptomyces: enzymes, natural products and development

JAR Worrall, E Vijgenboom - Natural product reports, 2010 - pubs.rsc.org
Covering: up to the end of 2009 The actinobacteria of the genus Streptomyces are of
immense importance to both ecological and human welfare. They produce a large number …

Dynamic changes in the extracellular proteome caused by absence of a pleiotropic regulator AdpA in Streptomyces griseus

G Akanuma, H Hara, Y Ohnishi… - Molecular …, 2009 - Wiley Online Library
In Streptomyces griseus, A‐factor (2‐isocapryloyl‐3R‐hydroxymethyl‐γ‐butyrolactone)
triggers morphological development and secondary metabolism by inducing a pleiotropic …