Systems biology based drug repositioning for development of cancer therapy
Drug repositioning is a powerful method that can assists the conventional drug discovery
process by using existing drugs for treatment of a disease rather than its original indication …
process by using existing drugs for treatment of a disease rather than its original indication …
Drug repositioning for effective prostate cancer treatment
Drug repositioning has gained attention from both academia and pharmaceutical companies
as an auxiliary process to conventional drug discovery. Chemotherapeutic agents have …
as an auxiliary process to conventional drug discovery. Chemotherapeutic agents have …
Integrative transcriptomics analysis of lung epithelial cells and identification of repurposable drug candidates for COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease, more commonly
COVID-19 has emerged as a world health pandemic. There are couples of treatment …
COVID-19 has emerged as a world health pandemic. There are couples of treatment …
Discovery of potent SARS-CoV-2 inhibitors from approved antiviral drugs via docking and virtual screening
Background: Coronavirus Disease 2019 (COVID-19) pandemic continues to threaten
patients, societies and healthcare systems around the world. There is an urgent need to …
patients, societies and healthcare systems around the world. There is an urgent need to …
Identification of prognostic biomarker signatures and candidate drugs in colorectal cancer: insights from systems biology analysis
Background and objectives: Colorectal cancer (CRC) is the second most common cause of
cancer-related death in the world, but early diagnosis ameliorates the survival of CRC. This …
cancer-related death in the world, but early diagnosis ameliorates the survival of CRC. This …
Repositioning of anti-inflammatory drugs for the treatment of cervical cancer sub-types
Cervical cancer is the fourth most commonly diagnosed cancer worldwide and, in almost all
cases is caused by infection with highly oncogenic Human Papillomaviruses (HPVs). On the …
cases is caused by infection with highly oncogenic Human Papillomaviruses (HPVs). On the …
Drug targeting and biomarkers in head and neck cancers: insights from systems biology analyses
The head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers
in the world, but robust biomarkers and diagnostics are still not available. This study …
in the world, but robust biomarkers and diagnostics are still not available. This study …
Overcoming drug resistance in advanced prostate cancer by drug repurposing
Prostate cancer (PCa) is the second most common cancer in men. Common treatments
include active surveillance, surgery, or radiation. Androgen deprivation therapy and …
include active surveillance, surgery, or radiation. Androgen deprivation therapy and …
Immune cell-specific and common molecular signatures in rheumatoid arthritis through molecular network approaches
B Comertpay, E Gov - Biosystems, 2023 - Elsevier
Rheumatoid arthritis (RA) is an autoimmune disorder and common symptom of RA is chronic
synovial inflammation. The pathogenesis of RA is not fully understood. Therefore, we aimed …
synovial inflammation. The pathogenesis of RA is not fully understood. Therefore, we aimed …
Multi-omic data interpretation to repurpose subtype specific drug candidates for breast cancer
Triple-negative breast cancer (TNBC), which is largely synonymous with the basal-like
molecular subtype, is the 5th leading cause of cancer deaths for women in the United States …
molecular subtype, is the 5th leading cause of cancer deaths for women in the United States …