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Cellular and molecular pathophysiology of traumatic brain injury: what have we learned so far?
Simple Summary Traumatic brain injury (TBI) is a catastrophic event to the health and life of
its sufferers, and it also affects their relatives. In addition to the underlying complications of …
its sufferers, and it also affects their relatives. In addition to the underlying complications of …
Inflammasome activation in traumatic brain injury and Alzheimer's disease
Traumatic brain injury (TBI) and Alzheimer's disease (AD) represent 2 of the largest sources
of death and disability in the United States. Recent studies have identified TBI as a potential …
of death and disability in the United States. Recent studies have identified TBI as a potential …
[HTML][HTML] Intranasally administered human MSC-derived extracellular vesicles inhibit NLRP3-p38/MAPK signaling after TBI and prevent chronic brain dysfunction
Traumatic brain injury (TBI) leads to lasting brain dysfunction with chronic
neuroinflammation typified by nucleotide-binding domain leucine-rich repeat and pyrin …
neuroinflammation typified by nucleotide-binding domain leucine-rich repeat and pyrin …
ACT001 attenuates microglia-mediated neuroinflammation after traumatic brain injury via inhibiting AKT/NFκB/NLRP3 pathway
Background Microglia-mediated neuroinflammatory response following traumatic brain
injury (TBI) is considered as a vital secondary injury factor, which drives trauma-induced …
injury (TBI) is considered as a vital secondary injury factor, which drives trauma-induced …
The NLRP3 inflammasome: an emerging therapeutic target for chronic pain
Chronic pain affects the life quality of the suffering patients and posts heavy problems to the
health care system. Conventional medications are usually insufficient for chronic pain …
health care system. Conventional medications are usually insufficient for chronic pain …
Neuroinflammation following traumatic brain injury: take it seriously or not
R Zheng, K Lee, Z Qi, Z Wang, Z Xu, X Wu… - Frontiers in …, 2022 - frontiersin.org
Traumatic brain injury (TBI) is associated with high mortality and disability, with a substantial
socioeconomic burden. With the standardization of the treatment process, there is increasing …
socioeconomic burden. With the standardization of the treatment process, there is increasing …
Targeting Nrf2‐Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals
AG Wu, YY Yong, YR Pan, L Zhang… - Oxidative Medicine …, 2022 - Wiley Online Library
Traumatic brain injury (TBI), known as mechanical damage to the brain, impairs the normal
function of the brain seriously. Its clinical symptoms manifest as behavioral impairment …
function of the brain seriously. Its clinical symptoms manifest as behavioral impairment …
TLR4 aggravates microglial pyroptosis by promoting DDX3X‐mediated NLRP3 inflammasome activation via JAK2/STAT1 pathway after spinal cord injury
J Wang, F Zhang, H Xu, H Yang… - Clinical and …, 2022 - Wiley Online Library
Background Toll‐like receptor 4 (TLR4) participates in the initiation of neuroinflammation in
various neurological diseases, including central nervous system injuries. NLR family pyrin …
various neurological diseases, including central nervous system injuries. NLR family pyrin …
Targeting inflammasomes to treat neurological diseases
Inflammasomes are multimeric protein complexes that can sense a plethora of microbe‐and
damage‐associated molecular signals. They play important roles in innate immunity and are …
damage‐associated molecular signals. They play important roles in innate immunity and are …
Maraviroc promotes recovery from traumatic brain injury in mice by suppression of neuroinflammation and activation of neurotoxic reactive astrocytes
XL Liu, DD Sun, MT Zheng, XT Li, HH Niu… - Neural regeneration …, 2023 - journals.lww.com
Neuroinflammation and the NACHT, LRR, and PYD domains-containing protein 3
inflammasome play crucial roles in secondary tissue damage following an initial insult in …
inflammasome play crucial roles in secondary tissue damage following an initial insult in …