Toll-like receptors and the control of immunity
The study of innate immunity and its link to inflammation and host defense encompasses
diverse areas of biology, ranging from genetics and biophysics to signal transduction and …
diverse areas of biology, ranging from genetics and biophysics to signal transduction and …
The history of Toll-like receptors—redefining innate immunity
The discovery of Toll-like receptors (TLRs) was an important event for immunology research
and was recognized as such with the awarding of the 2011 Nobel Prize in Physiology or …
and was recognized as such with the awarding of the 2011 Nobel Prize in Physiology or …
Invited review: bacterial lipopolysaccharides and innate immunity
C Alexander, ET Rietschel - Journal of endotoxin research, 2001 - journals.sagepub.com
Bacterial lipopolysaccharides (LPS) are the major outer surface membrane components
present in almost all Gram-negative bacteria and act as extremely strong stimulators of …
present in almost all Gram-negative bacteria and act as extremely strong stimulators of …
Intestinal barrier and permeability in health, obesity and NAFLD
The largest surface of the human body exposed to the external environment is the gut. At this
level, the intestinal barrier includes luminal microbes, the mucin layer, gastrointestinal …
level, the intestinal barrier includes luminal microbes, the mucin layer, gastrointestinal …
Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin.
RJ Ulevitch, PS Tobias - Annual review of immunology, 1995 - europepmc.org
In humans and experimental animals the presence of bacterial lipopolysaccharide
(endotoxin, LPS) signals the presence of gram-negative bacteria. Recognition of LPS …
(endotoxin, LPS) signals the presence of gram-negative bacteria. Recognition of LPS …
Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
Vertebrates and invertebrates initiate a series of defence mechanisms following infection by
Gram-negative bacteria by sensing the presence of lipopolysaccharide (LPS), a major …
Gram-negative bacteria by sensing the presence of lipopolysaccharide (LPS), a major …
Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock
Bacterial sepsis and septic shock result from the overproduction of inflammatory mediators
as a consequence of the interaction of the immune system with bacteria and bacterial wall …
as a consequence of the interaction of the immune system with bacteria and bacterial wall …
Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14.
E Hailman, HS Lichenstein, MM Wurfel… - The Journal of …, 1994 - rupress.org
CD14 is a 55-kD protein found as a glycosylphosphatidylinositol (GPI)-anchored protein on
the surface of monocytes, macrophages, and polymorphonuclear leukocytes, and as a …
the surface of monocytes, macrophages, and polymorphonuclear leukocytes, and as a …
Endotoxin signal transduction in macrophages
Through its action on macrophages, bacterial lipopolysaccharide (LPS) or endotoxin can
trigger responses that are protective or injurious to the host. This review examines the effects …
trigger responses that are protective or injurious to the host. This review examines the effects …
Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14.
J Pugin, CC Schürer-Maly, D Leturcq… - Proceedings of the …, 1993 - National Acad Sciences
Myeloid cell activation by lipopolysaccharides (LPS) involves two proteins, plasma LPS-
binding protein (LBP) and cell-membrane CD14. Cell membrane CD14, anchored by a …
binding protein (LBP) and cell-membrane CD14. Cell membrane CD14, anchored by a …