The Perseus computational platform for comprehensive analysis of (prote) omics data
A main bottleneck in proteomics is the downstream biological analysis of highly multivariate
quantitative protein abundance data generated using mass-spectrometry-based analysis …
quantitative protein abundance data generated using mass-spectrometry-based analysis …
A brave new world of RNA-binding proteins
RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one
or multiple globular RNA-binding domains (RBDs) and change the fate or function of the …
or multiple globular RNA-binding domains (RBDs) and change the fate or function of the …
STRING v10: protein–protein interaction networks, integrated over the tree of life
The many functional partnerships and interactions that occur between proteins are at the
core of cellular processing and their systematic characterization helps to provide context in …
core of cellular processing and their systematic characterization helps to provide context in …
Proteogenomic characterization reveals therapeutic vulnerabilities in lung adenocarcinoma
To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors …
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors …
PhosphoSitePlus, 2014: mutations, PTMs and recalibrations
Abstract PhosphoSitePlus®(PSP, http://www. phosphosite. org/), a knowledgebase
dedicated to mammalian post-translational modifications (PTMs), contains over 330 000 non …
dedicated to mammalian post-translational modifications (PTMs), contains over 330 000 non …
ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization
G Yu, LG Wang, QY He - Bioinformatics, 2015 - academic.oup.com
ChIPseeker is an R package for annotating ChIP-seq data analysis. It supports annotating
ChIP peaks and provides functions to visualize ChIP peaks coverage over chromosomes …
ChIP peaks and provides functions to visualize ChIP peaks coverage over chromosomes …
Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches
J Beermann, MT Piccoli, J Viereck… - Physiological …, 2016 - journals.physiology.org
Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …
coding transcripts with unknown function. There are several types of non-coding linear …
Virtual microdissection identifies distinct tumor-and stroma-specific subtypes of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains a lethal disease with a 5-year survival
rate of 4%. A key hallmark of PDAC is extensive stromal involvement, which makes …
rate of 4%. A key hallmark of PDAC is extensive stromal involvement, which makes …
Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma
Y Jiang, A Sun, Y Zhao, W Ying, H Sun, X Yang, B ** …
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants
Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the
elderly, with limited therapeutic options. Here we report on a study of> 12 million variants …
elderly, with limited therapeutic options. Here we report on a study of> 12 million variants …