A brave new world of RNA-binding proteins

MW Hentze, A Castello, T Schwarzl… - Nature reviews Molecular …, 2018 - nature.com
RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one
or multiple globular RNA-binding domains (RBDs) and change the fate or function of the …

[HTML][HTML] Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches

J Beermann, MT Piccoli, J Viereck… - Physiological …, 2016 - journals.physiology.org
Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …

Exploring epigenomic datasets by ChIPseeker

Q Wang, M Li, T Wu, L Zhan, L Li, M Chen… - Current …, 2022 - Wiley Online Library
In many aspects of life, epigenetics, or the altering of phenotype without changes in
sequences, play an essential role in biological function. A vast number of epigenomic …

Proteogenomic characterization reveals therapeutic vulnerabilities in lung adenocarcinoma

MA Gillette, S Satpathy, S Cao, SM Dhanasekaran… - Cell, 2020 - cell.com
To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors …

Undulating changes in human plasma proteome profiles across the lifespan

B Lehallier, D Gate, N Schaum, T Nanasi, SE Lee… - Nature medicine, 2019 - nature.com
Aging is a predominant risk factor for several chronic diseases that limit healthspan.
Mechanisms of aging are thus increasingly recognized as potential therapeutic targets …

Pan-cancer computational histopathology reveals mutations, tumor composition and prognosis

Y Fu, AW Jung, RV Torne, S Gonzalez, H Vöhringer… - Nature cancer, 2020 - nature.com
We use deep transfer learning to quantify histopathological patterns across 17,355
hematoxylin and eosin-stained histopathology slide images from 28 cancer types and …

MIENTURNET: an interactive web tool for microRNA-target enrichment and network-based analysis

V Licursi, F Conte, G Fiscon, P Paci - BMC bioinformatics, 2019 - Springer
Background miRNAs regulate the expression of several genes with one miRNA able to
target multiple genes and with one gene able to be simultaneously targeted by more than …

Lung adenocarcinoma and lung squamous cell carcinoma cancer classification, biomarker identification, and gene expression analysis using overlap** feature …

JW Chen, J Dhahbi - Scientific reports, 2021 - nature.com
Lung cancer is one of the deadliest cancers in the world. Two of the most common subtypes,
lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), have drastically …

Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways

M Nagel, PR Jansen, S Stringer, K Watanabe… - Nature …, 2018 - nature.com
Neuroticism is an important risk factor for psychiatric traits, including depression, anxiety,,
and schizophrenia,–. At the time of analysis, previous genome-wide association studies …