Background Whole-genome sequencing (WGS) is the gold standard diagnostic tool to
identify and genetically characterise emerging pathogen mutations (variants), but cost …

Co-infections are a poorly understood aspect of tick-borne diseases. In the United States
alone, nineteen different tick-borne pathogens have been identified. The majority of these …

The RNA polymerase alternative σ factor RpoS in Borrelia burgdorferi (Bb), the Lyme
disease pathogen, is responsible for programmatic-positive and-negative gene regulation …

High-throughput sequencing (HTS) has revolutionized microbiology, but many microbes
exist at low abundance in their natural environment and/or are difficult, if not impossible, to …

Abstract Background In recent years, Babesia and Bartonella species co-infections in
patients with chronic, nonspecific illnesses have continued to challenge and change the …

Probe-based nucleic acid enrichment represents an effective route to enhance the detection
capacity of next-generation sequencing (NGS) in a set of clinically diverse and relevant …

More than one-hundred Babesia species that affect animals and humans have been
described, eight of which have been associated with emerging and underdiagnosed …

Francisella tularensis, the bacterium that causes the zoonosis tularemia, and its genetic near
neighbor species, can be difficult or impossible to cultivate from complex samples. Thus …

Piroplasms, which include the agents of cattle fever and human and dog babesiosis, are a
diverse group of blood parasites of significant veterinary and medical importance. The …

Ticks are known vectors of various pathogens, including bacteria, parasites and viruses, that
impact both animal and human health. Improving knowledge of the distribution of tick-borne …