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Matrix Architecture and Mechanics Regulate Myofibril Organization, Costamere Assembly, and Contractility in Engineered Myocardial Microtissues
The mechanical function of the myocardium is defined by cardiomyocyte contractility and the
biomechanics of the extracellular matrix (ECM). Understanding this relationship remains an …
biomechanics of the extracellular matrix (ECM). Understanding this relationship remains an …
A data-driven computational model for engineered cardiac microtissues
Engineered heart tissues (EHTs) present a potential solution to some of the current
challenges in the treatment of heart disease; however, the development of mature, adult-like …
challenges in the treatment of heart disease; however, the development of mature, adult-like …
MicroBundlePillarTrack: A Python package for automated segmentation, tracking, and analysis of pillar deflection in cardiac microbundles
Movies of human induced pluripotent stem cell (hiPSC)-derived engineered cardiac tissue
(microbundles) contain abundant information about structural and functional maturity …
(microbundles) contain abundant information about structural and functional maturity …
Generating in-silico Models of Engineered Heart Tissues: The Importance of Using Length-Dependent Activation
Engineered heart tissues (EHTs) are a promising technology to improve cardiac disease
treatment. However, manufacturing EHTs with mature iPSC-CMs remains a challenge due …
treatment. However, manufacturing EHTs with mature iPSC-CMs remains a challenge due …