Targeting oral tumor microenvironment for effective therapy

HS Budi, B Farhood - Cancer Cell International, 2023 - Springer
Oral cancers are among the common head and neck malignancies. Different anticancer
therapy modalities such as chemotherapy, immunotherapy, radiation therapy, and also …

2-Phenethylamines in medicinal chemistry: A review

CT Nieto, A Manchado, L Belda, D Diez, NM Garrido - Molecules, 2023 - mdpi.com
A concise review covering updated presence and role of 2-phenethylamines in medicinal
chemistry is presented. Open-chain, flexible alicyclic amine derivatives of this motif are …

Mouse tumor-bearing models as preclinical study platforms for oral squamous cell carcinoma

Q Li, H Dong, G Yang, Y Song, Y Mou, Y Ni - Frontiers in oncology, 2020 - frontiersin.org
Preclinical animal models of oral squamous cell carcinoma (OSCC) have been extensively
studied in recent years. Investigating the pathogenesis and potential therapeutic strategies …

[HTML][HTML] Unmet needs and perspectives in oral cancer prevention

J Bouaoud, P Bossi, M Elkabets, S Schmitz… - Cancers, 2022 - mdpi.com
Simple Summary Oral cavity is the most common site of head and neck cancer which is
ranked as the eighth most common cancer worldwide. Oral cancer treatment is often …

Multifunctional photodynamic/photothermal nano-agents for the treatment of oral leukoplakia

L Lin, C Song, Z Wei, H Zou, S Han, Z Cao… - Journal of …, 2022 - Springer
Oral leukoplakia (OLK) has gained extensive attention because of the potential risk for
malignant transformation. Photosensitizers (PSs) played an indispensable role in the …

Genomic and transcriptomic landscape of an oral squamous cell carcinoma mouse model for immunotherapy

YM Lee, CL Hsu, YH Chen, DL Ou, C Hsu… - Cancer Immunology …, 2023 - aacrjournals.org
The immune checkpoint inhibitor (ICI), anti–programmed death-1 (anti–PD-1), has shown
moderate efficacy in some patients with head and neck squamous cell carcinoma (HNSCC) …

4NQO induced carcinogenesis: A mouse model for oral squamous cell carcinoma

SH Sagheer, D Whitaker-Menezes, JYS Han… - Methods in Cell …, 2021 - Elsevier
Oral squamous cell carcinoma (OSCC) is the most common subsite of head and neck
cancer, with a 5-year survival rate of only 50%. There is a pressing need for animal models …

Multistage targeted “Photoactive neutrophil” for enhancing synergistic photo-chemotherapy

Y Xu, X Zhang, G Hu, X Wu, Y Nie, H Wu, D Kong… - Biomaterials, 2021 - Elsevier
Cell-based drug delivery system holds a great promise in anticancer treatment, due to its
potential of maximizing therapeutic efficacy while minimizing adverse effects. However …

ICI-based therapies: A new strategy for oral potentially malignant disorders

T Wang, S Sun, X Zeng, J Li - Oral Oncology, 2023 - Elsevier
Oral potentially malignant disorders (OPMDs) are linked with an escalated risk of develo**
cancers, particularly oral squamous cell carcinoma (OSCC). Since prevailing therapies …

[HTML][HTML] Mouse models for immune checkpoint blockade therapeutic research in oral cancer

WC Chiu, DL Ou, CT Tan - International Journal of Molecular Sciences, 2022 - mdpi.com
The most prevalent oral cancer globally is oral squamous cell carcinoma (OSCC). The
invasion of adjacent bones and the metastasis to regional lymph nodes often lead to poor …