Mesenchymal stem cell-derived exosomes: therapeutic opportunities and challenges for spinal cord injury

W Liu, Z Ma, J Li, X Kang - Stem cell research & therapy, 2021 - Springer
Spinal cord injury (SCI) often leads to serious motor and sensory dysfunction of the limbs
below the injured segment. SCI not only results in physical and psychological harm to …

Modern medical management of spinal cord injury

M Karsy, G Hawryluk - Current Neurology and Neuroscience Reports, 2019 - Springer
Abstract Purpose of Review Spinal cord injury (SCI) shows an incidence of 10.4–83
cases/million/year globally and remains a significant source of morbidity and cost to society …

The influence of timing of surgical decompression for acute spinal cord injury: a pooled analysis of individual patient data

JH Badhiwala, JR Wilson, CD Witiw, JS Harrop… - The Lancet …, 2021 - thelancet.com
Background Although there is a strong biological rationale for early decompression of the
injured spinal cord, the influence of the timing of surgical decompression for acute spinal …

Neurological recovery following traumatic spinal cord injury: a systematic review and meta-analysis

MH Khorasanizadeh, M Yousefifard, M Eskian… - … of Neurosurgery: Spine, 2019 - thejns.org
OBJECTIVE Predicting neurological recovery following traumatic spinal cord injury (TSCI) is
a complex task considering the heterogeneous nature of injury and the inconsistency of …

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

JW Squair, M Gautier, L Mahe, JE Soriano, A Rowald… - Nature, 2021 - nature.com
Spinal cord injury (SCI) induces haemodynamic instability that threatens survival,–, impairs
neurological recovery,, increases the risk of cardiovascular disease,, and reduces quality of …

Recent update on basic mechanisms of spinal cord injury

SA Quadri, M Farooqui, A Ikram, A Zafar, MA Khan… - Neurosurgical …, 2020 - Springer
Spinal cord injury (SCI) is a life-shattering neurological condition that affects between
250,000 and 500,000 individuals each year with an estimated two to three million people …

Management of acute traumatic spinal cord injury: a review of the literature

TY Wang, C Park, H Zhang, S Rahimpour… - Frontiers in …, 2021 - frontiersin.org
Traumatic spinal cord injury (TSCI) is a debilitating disease that poses significant functional
and economic burden on both the individual and societal levels. Prognosis is dependent on …

A new framework for investigating the biological basis of degenerative cervical myelopathy [AO Spine RECODE-DCM Research Priority Number 5]: mechanical stress …

BM Davies, O Mowforth, AA Gharooni… - Global Spine …, 2022 - journals.sagepub.com
Study Design Literature Review (Narrative) Objective To propose a new framework, to
support the investigation and understanding of the pathobiology of DCM, AO Spine …

Pathophysiology of spinal cord injury

LD Hachem, MG Fehlings - Neurosurgery Clinics, 2021 - neurosurgery.theclinics.com
Spinal cord injury (SCI) triggers a complex cascade of molecular and chemical events that
leads to progressive cell loss and tissue damage. 1, 2 Nearly a century of fundamental basic …

Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial

C Moritz, EC Field-Fote, C Tefertiller, I van Nes… - Nature medicine, 2024 - nature.com
Cervical spinal cord injury (SCI) leads to permanent impairment of arm and hand functions.
Here we conducted a prospective, single-arm, multicenter, open-label, non-significant risk …