[HTML][HTML] Sulforaphane: A broccoli bioactive phytocompound with cancer preventive potential

AE Kaiser, M Baniasadi, D Giansiracusa… - Cancers, 2021 - mdpi.com
Simple Summary As of the past decade, phytochemicals have become a major target of
interest in cancer chemopreventive and chemotherapeutic research. Sulforaphane (SFN) is …

[HTML][HTML] Anti-carcinogenic glucosinolates in cruciferous vegetables and their antagonistic effects on prevention of cancers

P Soundararajan, JS Kim - Molecules, 2018 - mdpi.com
Glucosinolates (GSL) are naturally occurring β-d-thioglucosides found across the
cruciferous vegetables. Core structure formation and side-chain modifications lead to the …

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

TD Hubbard, IA Murray, WH Bisson, TS Lahoti… - Scientific reports, 2015 - nature.com
Ligand activation of the aryl hydrocarbon (AHR) has profound effects upon the
immunological status of the gastrointestinal tract, establishing and maintaining signaling …

Sulforaphane in broccoli: The green chemoprevention!! Role in cancer prevention and therapy

DB Nandini, RS Rao, BS Deepak… - Journal of oral and …, 2020 - journals.lww.com
Isothicyanates present in cruciferous vegetables are known to exhibit chemoprevention by
various mechanisms. Presently, there is growing evidence that a phytochemical compound …

Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment

M Russo, C Spagnuolo, GL Russo… - Critical reviews in …, 2018 - Taylor & Francis
In the past decades, extensive studies have reported the potential chemopreventive activity
of sulforaphane, an isothiocyanate derived from glucoraphanin, occurring in large amounts …

Dietary sulforaphane in cancer chemoprevention: the role of epigenetic regulation and HDAC inhibition

SM Tortorella, SG Royce, PV Licciardi… - Antioxidants & redox …, 2015 - liebertpub.com
Significance: Sulforaphane, produced by the hydrolytic conversion of glucoraphanin after
ingestion of cruciferous vegetables, particularly broccoli and broccoli sprouts, has been …

Anticancer activity of sulforaphane: the epigenetic mechanisms and the Nrf2 signaling pathway

X Su, X Jiang, L Meng, X Dong… - Oxidative medicine and …, 2018 - Wiley Online Library
Sulforaphane (SFN), a compound derived from cruciferous vegetables that has been shown
to be safe and nontoxic, with minimal/no side effects, has been extensively studied due to its …

The role of isothiocyanates as cancer chemo-preventive, chemo-therapeutic and anti-melanoma agents

M Mitsiogianni, G Koutsidis, N Mavroudis, DT Trafalis… - Antioxidants, 2019 - mdpi.com
Many studies have shown evidence in support of the beneficial effects of phytochemicals in
preventing chronic diseases, including cancer. Among such phytochemicals, sulphur …

Mechanisms underlying biological effects of cruciferous glucosinolate-derived isothiocyanates/indoles: a focus on metabolic syndrome

M Esteve - Frontiers in Nutrition, 2020 - frontiersin.org
An inverse correlation between vegetable consumption and the incidence of cancer has
long been described. This protective effect is stronger when cruciferous vegetables are …

Molecular targets of isothiocyanates in cancer: recent advances

P Gupta, B Kim, SH Kim… - Molecular nutrition & food …, 2014 - Wiley Online Library
Cancer is a multistep process resulting in uncontrolled cell division. It results from aberrant
signaling pathways that lead to uninhibited cell division and growth. Various recent …