The peripheral mature T cell pool is regulated by complex homeostatic mechanisms. Naive
T cells are maintained by interleukin-7 (IL-7) and T cell receptor (TCR) signaling from …

Abstract Interleukin-2 and interleukin-15 have pivotal roles in the control of the life and death
of lymphocytes. Although their heterotrimeric receptors have two receptor subunits in …

We report intriguing aspects of the contribution of IL-15Rα to IL-15 functions. Consistent with
high-affinity interactions between IL-15 and IL-15Rα, these two molecules form stable …

Evidence has accumulated that cytokines have a fundamental role in the differentiation of
memory T cells. Here, we follow the CD8+ T cell from initial activation to memory-cell …

Natural killer (NK) cells are important effector cells in the control of infections. The cellular
and molecular signals required for NK cell activation in vivo remain poorly defined. By using …

Abstract IL-2, IL-15, and IL-7 are cytokines that are critical for regulating lymphoid
homeostasis. These cytokines stimulate similar responses from lymphocytes in vitro, but play …

Simple Summary Emerging knowledge of the two type I cytokine family members IL-2 and IL-
15 has led to critical therapeutic implications for cancer treatment. Here we discuss the …

Natural killer (NK) cells are lymphocytes primarily involved in innate immunity and possess
important functional properties in anti-viral and anti-tumor responses; thus, these cells have …

Memory T cells can persist for extended periods in the absence of antigen, and long-term T
cell immunity is often seen after acute infections. Paradoxically, there have been …

We know how B and T cells develop, what they'see'and the receptors they'see with'. By
contrast, and despite an unprecedented increase in the number of receptors and ligands …