Glioblastoma multiforme (GBM) is an aggressive brain tumor with high mortality rates. Due to
its invasiveness, heterogeneity, and incomplete resection, the treatment is very challenging …

In the last decade, many small molecules, usually characterized by heterocyclic scaffolds,
have been designed and synthesized as tyrosine kinase inhibitors (TKIs). Among them …

Nuak1 (NUAK family SnF1-like kinase-1) is a serine-threonine kinase and a member of the
AMPK family. Interest in Nuak1 has increased over the years due to the role it plays in …

Neuroblastoma (NB) is one of the most frequently occurring neurogenic extracranial solid
cancers in childhood and infancy. Over the years, many pieces of evidence suggested that …

Neuroblastoma (NB) is a pediatric cancer with high clinical and molecular heterogeneity,
and patients with high-risk tumors have limited treatment options. Receptor tyrosine kinase …

Patients with advanced neuroblastoma (NB) receive multimodal clinical therapy, including
the potent anthracycline chemotherapy drug doxorubicin (Dox). The acquisition of Dox …

Long-chain imidazole-based ionic liquids (compounds 2, 4, 9) and lysosomotropic
detergents (compounds 7, 3, 8) with potent anticancer activity were synthesized. Their …

Neuroblastoma is the most common malignant tumor of infancy and accounts for 10% of all
childhood cancers. The high biological and clinical heterogeneity of this tumor leads to …