Insulin and insulin-like growth factor 1 (IGF1) signalling play a central role in the
development and maintenance of neurons in the brain, and human neurodevelopmental as …

Neurons are highly dependent on mitochondrial ATP production and Ca2+ buffering.
Neurons have unique compartmentalized anatomy and energy requirements, and each …

Abstract Background Sporadic Alzheimer's disease (AD) occurs in 99% of all cases and can
be influenced by air pollution such as diesel emissions and more recently, an iron oxide …

Acute ocular hypertension (AOH) is the most important characteristic of acute glaucoma,
which can lead to retinal ganglion cell (RGC) death and permanent vision loss. So far …

Background Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction,
characterized by cognitive and memory impairments closely linked to hippocampal …

Background Multiple observational studies have reported substantial comorbidity between
neuropsychiatric disorders and cardiovascular disease (CVD), but the underlying …

Background Alzheimer's disease is characterized by abnormal β-amyloid (Aβ) plaque
accumulation, tau hyperphosphorylation, reactive oxidative stress, mitochondrial dysfunction …

Growth-factor-induced cell signaling plays a crucial role in development; however, negative
regulation of this signaling pathway is important for sustaining homeostasis and preventing …

Schizophrenia is a group of severe mental disorders. ZBTB20 is critical in brain
development and corticogenesis and its dysfunction induces various neural disorders …

Metabolic syndrome (MetS) has become a worldwide public health problem with increasing
global morbidity. Existing surgical and pharmaceutical treatments have certain side effects …