It is well known that cardiovascular diseases have a substantial heritable component, but the
precise genetic variants responsible for this familial tendency have been hard to uncover. In …

Long QT and short QT syndromes (LQTS and SQTS) are cardiac repolarization
abnormalities that are characterized by length perturbations of the QT interval as measured …

1From Mayo Clinic, Rochester, Minnesota; 2Fondazione Salvatore Maugeri University of
Pavia, Pavia, Italy and New York University, New York, New York; 3University Hospital …

Atrial fibrillation (AF) is a common cardiac arrhythmia whose molecular etiology is poorly
understood. We studied a family with hereditary persistent AF and identified the causative …

The Japanese Circulation Society (JCS) published the “Guidelines for Pharmacological
Treatment of Arrhythmia” in 2004, and a revised edition was published in 2009. 1 Both …

Sick sinus syndrome (SSS) describes an arrhythmia phenotype attributed to sinus node
dysfunction and diagnosed by electrocardiographic demonstration of sinus bradycardia or …

In children with structurally normal hearts, the mechanisms of arrhythmias are usually the
same as in the adult patient. Some arrhythmias are particularly associated with young age …

Brugada syndrome is a genetic disease associated with sudden cardiac death that is
characterized by ventricular fibrillation and right precordial ST segment elevation on ECG …

Sudden unexpected death in epilepsy (SUDEP) is the most common cause of death directly
related to epilepsy, and most frequently occurs in people with chronic epilepsy. The main …

Background—We studied a large family affected by an autosomal dominant cardiac
conduction disorder associated with sinus node dysfunction, arrhythmia, and right and …