Effectors of plant necrotrophic fungi

D Shao, DL Smith, M Kabbage, MG Roth - Frontiers in Plant Science, 2021 - frontiersin.org
Plant diseases caused by necrotrophic fungal pathogens result in large economic losses in
field crop production worldwide. Effectors are important players of plant-pathogen interaction …

The complex relationship between disease resistance and yield in crops

MC Derbyshire, TE Newman… - Plant Biotechnology …, 2024 - Wiley Online Library
In plants, growth and defence are controlled by many molecular pathways that are
antagonistic to one another. This results in a 'growth‐defence trade‐off', where plants …

Cblaster: a remote search tool for rapid identification and visualization of homologous gene clusters

CLM Gilchrist, TJ Booth, B van Wersch… - Bioinformatics …, 2021 - academic.oup.com
Motivation Genes involved in coordinated biological pathways, including metabolism, drug
resistance and virulence, are often collocalized as gene clusters. Identifying homologous …

Surface frustration re-patterning underlies the structural landscape and evolvability of fungal orphan candidate effectors

MC Derbyshire, S Raffaele - Nature Communications, 2023 - nature.com
Pathogens secrete effector proteins to subvert host physiology and cause disease. Effectors
are engaged in a molecular arms race with the host resulting in conflicting evolutionary …

Dehydroamino acid residues in bioactive natural products

S Wang, K Wu, YJ Tang, H Deng - Natural Product Reports, 2024 - pubs.rsc.org
Covering: 2000 to up to 2023 α, β-Dehydroamino acids (dhAAs) are unsaturated
nonproteinogenic amino acids found in a wide array of naturally occurring peptidyl …

Emulating nonribosomal peptides with ribosomal biosynthetic strategies

S Mordhorst, F Ruijne, AL Vagstad, OP Kuipers… - RSC Chemical …, 2023 - pubs.rsc.org
Peptide natural products are important lead structures for human drugs and many
nonribosomal peptides possess antibiotic activity. This makes them interesting targets for …

Molecular plant immunity against biotrophic, hemibiotrophic, and necrotrophic fungi

CL McCombe, JR Greenwood, PS Solomon… - Essays in …, 2022 - portlandpress.com
Pathogenic fungi use diverse infection strategies to obtain nutrients from plants. Biotrophic
fungi feed only on living plant tissue, whereas necrotrophic fungi kill host cells to extract …

The Venturia inaequalis effector repertoire is dominated by expanded families with predicted structural similarity, but unrelated sequence, to avirulence proteins from …

M Rocafort, JK Bowen, B Hassing, MP Cox, B McGreal… - BMC biology, 2022 - Springer
Background Scab, caused by the biotrophic fungus Venturia inaequalis, is the most
economically important disease of apples worldwide. During infection, V. inaequalis …

Out for a RiPP: challenges and advances in genome mining of ribosomal peptides from fungi

SC Kessler, YH Chooi - Natural Product Reports, 2022 - pubs.rsc.org
Covering up to June 2021 Ribosomally synthesized and post-translationally modified
peptides (RiPPs) from fungi are an underexplored class of natural products, despite their …

The unsung roles of microbial secondary metabolite effectors in the plant disease cacophony

LI Rangel, MD Bolton - Current Opinion in Plant Biology, 2022 - Elsevier
Plants counter disease with an array of responses to styme pathogen ingress. In contrast to
this cacophony, plant pathogens orchestrate a finely tuned repertoire of virulence …