Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

The complement system is a recognized pillar of host defence against infection and noxious
self-derived antigens. Complement is traditionally known as a serum-effective system …

Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-
mediated recycling of organelles and protein aggregates, as well as the destruction of …

The recognition of microbial or danger-associated molecular patterns by complement
proteins initiates a cascade of events that culminates in the activation of surface complement …

The crosstalk among the complement system, immune cells, and mediators of inflammation
provides an efficient mechanism to protect the organism against infections and support the …

Complement factor H (CFH) negatively regulates consumption of complement component 3
(C3), thereby restricting complement activation. Genetic variants in CFH predispose to …

Shigella spp. are diarrheal pathogens closely related to Escherichia coli. They are named
after Kiyoshi Shiga, who in 1898 identified its most virulent member, Shigella dysenteriae, as …

Cardiovascular diseases are the leading cause of death globally, and atherosclerosis is the
major contributor to the development and progression of cardiovascular diseases. Immune …

Antibody‐dependent complement activity is associated not only with autoimmune morbidity,
but also with antitumor efficacy. In infectious disease, both recombinant monoclonal …

The complement component C3 is a fundamental plasma protein for host defense, produced
largely by the liver. However, recent work has demonstrated the critical importance of tissue …