Mechanism of inhibition of Ebola virus RNA-dependent RNA polymerase by remdesivir

EP Tchesnokov, JY Feng, DP Porter, M Götte - Viruses, 2019 - mdpi.com
Remdesivir (GS-5734) is a 1′-cyano-substituted adenosine nucleotide analogue prodrug
that shows broad-spectrum antiviral activity against several RNA viruses. This compound is …

Targeting Fc effector function in vaccine design

SI Richardson, PL Moore - Expert Opinion on Therapeutic Targets, 2021 - Taylor & Francis
Introduction Antibodies mediate pathogen neutralization in addition to several cytotoxic Fc
functions through engaging cellular receptors and recruiting effector cells. Fc effector …

The ferret as a model for filovirus pathogenesis and countermeasure evaluation

Z Schiffman, G Liu, W Cao, W Zhu, K Emeterio… - ILAR …, 2020 - academic.oup.com
The domestic ferret (Mustela putorius furo) has long been a popular animal model for
evaluating viral pathogenesis and transmission as well as the efficacy of candidate …

A single-dose intranasal combination panebolavirus vaccine

DC Malherbe, JB Kimble, C Atyeo… - The Journal of …, 2023 - academic.oup.com
Abstract Background Ebolaviruses Ebola (EBOV), Sudan (SUDV), and Bundibugyo (BDBV)
cause severe human disease, which may be accompanied by hemorrhagic syndrome, with …

Modified vaccinia Ankara vaccine expressing Marburg virus-like particles protects guinea pigs from lethal Marburg virus infection

DC Malherbe, A Domi, MJ Hauser, M Meyer, BM Gunn… - npj Vaccines, 2020 - nature.com
We introduce a new vaccine platform against Marburg virus (MARV) combining the
advantages of the immunogenicity of a highly attenuated vaccine vector (Modified Vaccinia …

A single intranasal dose of human parainfluenza virus type 3-vectored vaccine induces effective antibody and memory T cell response in the lungs and protects …

PA Ilinykh, S Periasamy, K Huang, NA Kuzmina… - npj Vaccines, 2022 - nature.com
Respiratory tract vaccination has an advantage of needle-free delivery and induction of
mucosal immune response in the portal of SARS-CoV-2 entry. We utilized human …

A single immunization with a modified vaccinia Ankara vectored vaccine producing Sudan virus-like particles protects from lethal infection

DC Malherbe, A Domi, MJ Hauser, C Atyeo… - npj Vaccines, 2022 - nature.com
A new vectored vaccine MVA-VLP-SUDV was generated against Sudan ebolavirus (SUDV)
combining the advantages of the immunogenicity of a live attenuated vaccine vector …

From bivariate to multivariate analysis of cytometric data: overview of computational methods and their application in vaccination studies

S Lucchesi, S Furini, D Medaglini, A Ciabattini - Vaccines, 2020 - mdpi.com
Flow and mass cytometry are used to quantify the expression of multiple extracellular or
intracellular molecules on single cells, allowing the phenotypic and functional …

Macaque antibodies targeting Marburg virus glycoprotein induced by multivalent immunization

BM Janus, R Wang, TE Cleveland IV… - Journal of …, 2024 - journals.asm.org
Marburg virus infection in humans is associated with case fatality rates that can reach up to
90%, but to date, there are no approved vaccines or monoclonal antibody (mAb) …

Serum concentration of antigen-specific IgG can substantially bias interpretation of antibody-dependent phagocytosis assay readout

RS Germain, EL Bossard, L Corey, AM Sholukh - Iscience, 2023 - cell.com
Because virus neutralization cannot solely explain vaccine-induced, antibody-mediated
protection, antibody effector functions are being considered as a potential correlate of …