Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms
KR Stenmark, KA Fagan, MG Frid - Circulation research, 2006 - Am Heart Assoc
Chronic hypoxic exposure induces changes in the structure of pulmonary arteries, as well as
in the biochemical and functional phenotypes of each of the vascular cell types, from the …
in the biochemical and functional phenotypes of each of the vascular cell types, from the …
The critical role of pulmonary arterial compliance in pulmonary hypertension
The normal pulmonary circulation is a low-pressure, high-compliance system. Pulmonary
arterial compliance decreases in the presence of pulmonary hypertension because of …
arterial compliance decreases in the presence of pulmonary hypertension because of …
Hypoxia induces heart regeneration in adult mice
The adult mammalian heart is incapable of regeneration following cardiomyocyte loss,
which underpins the lasting and severe effects of cardiomyopathy. Recently, it has become …
which underpins the lasting and severe effects of cardiomyopathy. Recently, it has become …
Pulmonary vascular wall stiffness: an important contributor to the increased right ventricular afterload with pulmonary hypertension
Pulmonary hypertension (PH) is associated with structural and mechanical changes in the
pulmonary vascular bed that increase right ventricular (RV) afterload. These changes …
pulmonary vascular bed that increase right ventricular (RV) afterload. These changes …
[HTML][HTML] Pulmonary circulation at exercise
R Naeije, N Chesler - Comprehensive Physiology, 2012 - ncbi.nlm.nih.gov
The pulmonary circulation is a high flow and low pressure circuit, with an average resistance
of 1 mmHg. min. L− 1 in young adults, increasing to 2.5 mmHg. min. L− 1 over 4–6 decades …
of 1 mmHg. min. L− 1 in young adults, increasing to 2.5 mmHg. min. L− 1 over 4–6 decades …
Four‐dimensional flow assessment of pulmonary artery flow and wall shear stress in adult pulmonary arterial hypertension: Results from two institutions
Purpose To compare pulmonary artery flow using Cartesian and radially sampled four‐
dimensional flow‐sensitive (4D flow) MRI at two institutions. Methods Nineteen healthy …
dimensional flow‐sensitive (4D flow) MRI at two institutions. Methods Nineteen healthy …
Endothelial FGF signaling is protective in hypoxia-induced pulmonary hypertension
KV Woo, IY Shen, CJ Weinheimer… - The Journal of …, 2021 - Am Soc Clin Investig
Hypoxia-induced pulmonary hypertension (PH) is one of the most common and deadliest
forms of PH. Fibroblast growth factor receptors 1 and 2 (FGFR1/2) are elevated in patients …
forms of PH. Fibroblast growth factor receptors 1 and 2 (FGFR1/2) are elevated in patients …
Smooth muscle cell hypertrophy, proliferation, migration and apoptosis in pulmonary hypertension
T Tajsic, NW Morrell - Comprehensive Physiology, 2010 - Wiley Online Library
Pulmonary hypertension is a multifactorial disease characterized by sustained elevation of
pulmonary vascular resistance (PVR) and pulmonary arterial pressure (PAP). Central to the …
pulmonary vascular resistance (PVR) and pulmonary arterial pressure (PAP). Central to the …
Numerical methods for fluid–structure interaction models of aortic valves
G Marom - Archives of Computational Methods in Engineering, 2015 - Springer
In the recent years, fluid structure interaction (FSI) models of the aortic valve and root have
become increasingly common for two main reasons. The medical reason is that millions of …
become increasingly common for two main reasons. The medical reason is that millions of …
Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves
Extracellular matrix remodeling has been proposed as one mechanism by which proximal
pulmonary arteries stiffen during pulmonary arterial hypertension (PAH). Although some …
pulmonary arteries stiffen during pulmonary arterial hypertension (PAH). Although some …