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Computational implications of biophysical diversity and multiple timescales in neurons and synapses for circuit performance
Despite advances in experimental and theoretical neuroscience, we are still trying to identify
key biophysical details that are important for characterizing the operation of brain circuits …
key biophysical details that are important for characterizing the operation of brain circuits …
Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair
Due to its complex and multifaceted nature, develo** effective treatments for epilepsy is
still a major challenge. To deal with this complexity we introduce the concept of degeneracy …
still a major challenge. To deal with this complexity we introduce the concept of degeneracy …
Neuronal morphology enhances robustness to perturbations of channel densities
Biological neurons show significant cell-to-cell variability but have the striking ability to
maintain their key firing properties in the face of unpredictable perturbations and stochastic …
maintain their key firing properties in the face of unpredictable perturbations and stochastic …
The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow
Every neuron is part of a network, exerting its function by transforming multiple
spatiotemporal synaptic input patterns into a single spiking output. This function is specified …
spatiotemporal synaptic input patterns into a single spiking output. This function is specified …
Uncovering circuit mechanisms of current sinks and sources with biophysical simulations of primary visual cortex
Local field potential (LFP) recordings reflect the dynamics of the current source density
(CSD) in brain tissue. The synaptic, cellular, and circuit contributions to current sinks and …
(CSD) in brain tissue. The synaptic, cellular, and circuit contributions to current sinks and …
The enigmatic HCN channels: A cellular neurophysiology perspective
What physiological role does a slow hyperpolarization‐activated ion channel with mixed
cation selectivity play in the fast world of neuronal action potentials that are driven by …
cation selectivity play in the fast world of neuronal action potentials that are driven by …
Temperature compensation in a small rhythmic circuit
Temperature affects the conductances and kinetics of the ionic channels that underlie
neuronal activity. Each membrane conductance has a different characteristic temperature …
neuronal activity. Each membrane conductance has a different characteristic temperature …
Similar excitability through different sodium channels and implications for the analgesic efficacy of selective drugs
Nociceptive sensory neurons convey pain-related signals to the CNS using action
potentials. Loss-of-function mutations in the voltage-gated sodium channel Na V 1.7 cause …
potentials. Loss-of-function mutations in the voltage-gated sodium channel Na V 1.7 cause …
Neurodynamics
S Coombes, KCA Wedgwood - Texts in applied mathematics, 2023 - Springer
This is a book about 'Neurodynamics'. What we mean is that this is a book about how ideas
from dynamical systems theory have been developed and employed in recent years to give …
from dynamical systems theory have been developed and employed in recent years to give …
Transitions between classes of neuronal excitability and bifurcations induced by autapse
Z Zhao, H Gu - Scientific Reports, 2017 - nature.com
Neuronal excitabilities behave as the basic and important dynamics related to the transitions
between firing and resting states, and are characterized by distinct bifurcation types and …
between firing and resting states, and are characterized by distinct bifurcation types and …