Computational implications of biophysical diversity and multiple timescales in neurons and synapses for circuit performance

J Gjorgjieva, G Drion, E Marder - Current opinion in neurobiology, 2016 - Elsevier
Despite advances in experimental and theoretical neuroscience, we are still trying to identify
key biophysical details that are important for characterizing the operation of brain circuits …

Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair

TM Stöber, D Batulin, J Triesch, R Narayanan… - Communications …, 2023 - nature.com
Due to its complex and multifaceted nature, develo** effective treatments for epilepsy is
still a major challenge. To deal with this complexity we introduce the concept of degeneracy …

Neuronal morphology enhances robustness to perturbations of channel densities

Y Zang, E Marder - Proceedings of the National Academy of Sciences, 2023 - pnas.org
Biological neurons show significant cell-to-cell variability but have the striking ability to
maintain their key firing properties in the face of unpredictable perturbations and stochastic …

The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow

R Migliore, CA Lupascu, LL Bologna… - PLoS computational …, 2018 - journals.plos.org
Every neuron is part of a network, exerting its function by transforming multiple
spatiotemporal synaptic input patterns into a single spiking output. This function is specified …

Uncovering circuit mechanisms of current sinks and sources with biophysical simulations of primary visual cortex

AE Rimehaug, AJ Stasik, E Hagen, YN Billeh… - elife, 2023 - elifesciences.org
Local field potential (LFP) recordings reflect the dynamics of the current source density
(CSD) in brain tissue. The synaptic, cellular, and circuit contributions to current sinks and …

The enigmatic HCN channels: A cellular neurophysiology perspective

P Mishra, R Narayanan - Proteins: Structure, Function, and …, 2025 - Wiley Online Library
What physiological role does a slow hyperpolarization‐activated ion channel with mixed
cation selectivity play in the fast world of neuronal action potentials that are driven by …

Temperature compensation in a small rhythmic circuit

LM Alonso, E Marder - Elife, 2020 - elifesciences.org
Temperature affects the conductances and kinetics of the ionic channels that underlie
neuronal activity. Each membrane conductance has a different characteristic temperature …

Similar excitability through different sodium channels and implications for the analgesic efficacy of selective drugs

YF **e, J Yang, S Ratté, SA Prescott - Elife, 2024 - elifesciences.org
Nociceptive sensory neurons convey pain-related signals to the CNS using action
potentials. Loss-of-function mutations in the voltage-gated sodium channel Na V 1.7 cause …

Neurodynamics

S Coombes, KCA Wedgwood - Texts in applied mathematics, 2023 - Springer
This is a book about 'Neurodynamics'. What we mean is that this is a book about how ideas
from dynamical systems theory have been developed and employed in recent years to give …

Transitions between classes of neuronal excitability and bifurcations induced by autapse

Z Zhao, H Gu - Scientific Reports, 2017 - nature.com
Neuronal excitabilities behave as the basic and important dynamics related to the transitions
between firing and resting states, and are characterized by distinct bifurcation types and …