Autoimmunity may be generated by a variety of factors by creating a hyper-stimulated state
of the immune system. It had been established long ago that viruses are a substantial …

Multiple sclerosis (MS) is the most frequent chronic inflammatory disease of the CNS, and
imposes major burdens on young lives. Great progress has been made in understanding …

Objective Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the
cerebrospinal fluid (CSF), and are detectable at low concentrations in peripheral blood …

Neuro-axonal injury is a key factor in the development of permanent disability in multiple
sclerosis. Neurofilament light chain in peripheral blood has recently emerged as a biofluid …

Importance The causal direction and magnitude of the association between telomere length
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …

Volumetric variations of the human brain are heritable and are associated with many brain-
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …

Objective To characterize the accrual of long‐term disability in a cohort of actively treated
multiple sclerosis (MS) patients and to assess whether clinical and magnetic resonance …

Abstract The three-dimensional (3D) structure of chromatin is intrinsically associated with
gene regulation and cell function,–. Methods based on chromatin conformation capture have …

Multiple sclerosis is a common disease of the central nervous system in which the interplay
between inflammatory and neurodegenerative processes typically results in intermittent …

Multiple sclerosis (MS) is a common autoimmune disease that targets myelin in the central
nervous system (CNS). Multiple genome-wide association studies (GWAS) over the past 10 …