Role of nonresolving inflammation in hepatocellular carcinoma development and progression

LX Yu, Y Ling, HY Wang - NPJ precision oncology, 2018 - nature.com
Hepatocellular carcinoma (HCC) has become a leading cause of cancer-related death,
making the elucidation of its underlying mechanisms an urgent priority. Inflammation is an …

MicroRNAs in the pathogenesis of hepatocellular carcinoma: A review

A Morishita, K Oura, T Tadokoro, K Fujita, J Tani… - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is one of the most frequently occurring
cancers, and the prognosis for late-stage HCC remains poor. A better understanding of the …

The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer

X Zheng, M Huang, L **ng, R Yang, X Wang, R Jiang… - Molecular cancer, 2020 - Springer
Background Increasing studies have shown that circRNA is closely related to the
carcinogenesis and development of many cancers. However, biological functions and the …

Tumor-derived exosomal circPSMA1 facilitates the tumorigenesis, metastasis, and migration in triple-negative breast cancer (TNBC) through miR-637/Akt1/β-catenin …

S Yang, D Wang, S Zhong, W Chen, F Wang… - Cell death & …, 2021 - nature.com
Circular RNAs (circRNAs) are increasingly gaining importance and attention due to their
diverse potential functions and their value as diagnostic biomarkers (disease specific). This …

MicroRNA-188-5p suppresses tumor cell proliferation and metastasis by directly targeting FGF5 in hepatocellular carcinoma

F Fang, R Chang, L Yu, X Lei, S **ao, H Yang… - Journal of …, 2015 - Elsevier
Background & Aims Hepatocellular carcinoma (HCC) is one of the most common
malignancies worldwide. However, the detailed molecular mechanisms underlying HCC …

circHIPK3 promotes oxaliplatin-resistance in colorectal cancer through autophagy by sponging miR-637

Y Zhang, C Li, X Liu, Y Wang, R Zhao, Y Yang… - …, 2019 - thelancet.com
Background Resistance to oxaliplatin-based chemotherapy is a major cause of recurrence
in colorectal cancer (CRC) patients. There is increasing evidence indicating that circHIPK3 …

Jak-stat signaling induced by interleukin-6 family cytokines in hepatocellular carcinoma

J Lokau, V Schoeder, J Haybaeck, C Garbers - Cancers, 2019 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. It
can be caused by chronic liver cell injury with resulting sustained inflammation, eg, triggered …

Hotair mediates hepatocarcinogenesis through suppressing miRNA-218 expression and activating P14 and P16 signaling

WM Fu, X Zhu, WM Wang, YF Lu, BG Hu, H Wang… - Journal of …, 2015 - Elsevier
Background & Aims Long non-coding RNA Hotair has been considered as a pro-oncogene
in multiple cancers. Although there is emerging evidence that reveals its biological function …

[HTML][HTML] STAT proteins–key regulators of anti-viral responses, inflammation, and tumorigenesis in the liver

B Gao, H Wang, F Lafdil, D Feng - Journal of hepatology, 2012 - Elsevier
Since its discovery in the early 1990s, the Janus kinase (JAK)-signal transducer and
activator of transcription (STAT) signaling pathway has been found to play key roles in …

Exploring the JAK/STAT signaling pathway in hepatocellular carcinoma: unraveling signaling complexity and therapeutic implications

H Park, S Lee, J Lee, H Moon, SW Ro - International Journal of Molecular …, 2023 - mdpi.com
Hepatocellular Carcinoma (HCC) continues to pose a substantial global health challenge
due to its high incidence and limited therapeutic options. In recent years, the Janus Kinase …