[HTML][HTML] Osteoarthritis year in review 2021: epidemiology & therapy

JG Quicke, PG Conaghan, N Corp, G Peat - Osteoarthritis and cartilage, 2022 - Elsevier
This “Year in review” presents a selection of research themes and individual studies from the
clinical osteoarthritis (OA) field (epidemiology and therapy) and includes noteworthy …

Mesenchymal stromal cell-based therapy for cartilage regeneration in knee osteoarthritis

XN **ang, SY Zhu, HC He, X Yu, Y Xu… - Stem cell research & …, 2022 - Springer
Osteoarthritis, as a degenerative disease, is a common problem and results in high
socioeconomic costs and rates of disability. The most commonly affected joint is the knee …

Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success

G Copp, KP Robb, S Viswanathan - Cellular & Molecular Immunology, 2023 - nature.com
Osteoarthritis (OA) is a degenerative multifactorial disease with concomitant structural,
inflammatory, and metabolic changes that fluctuate in a temporal and patient-specific …

Cartilage regeneration and inflammation modulation in knee osteoarthritis following injection of allogeneic adipose-derived mesenchymal stromal cells: a phase II …

B Sadri, M Hassanzadeh, A Bagherifard… - Stem cell research & …, 2023 - Springer
Background Intra-articular injection of mesenchymal stromal cells (MSCs) with
immunomodulatory features and their paracrine secretion of regenerative factors proposed a …

Intra-articular mesenchymal stem cell injection for knee osteoarthritis: mechanisms and clinical evidence

P Wei, R Bao - International Journal of Molecular Sciences, 2022 - mdpi.com
Knee osteoarthritis presents higher incidences than other joints, with increased prevalence
during aging. It is a progressive process and may eventually lead to disability. Mesenchymal …

Clinical trials with mesenchymal stem cell therapies for osteoarthritis: challenges in the regeneration of articular cartilage

DC Carneiro, LT Araújo, GC Santos… - International Journal of …, 2023 - mdpi.com
Osteoarthritis (OA) is a whole-joint disease primarily characterized by the deterioration of
hyaline cartilage. Current treatments include microfracture and chondrocyte implantation as …

Efficacy and safety of platelet-rich plasma injections for the treatment of osteoarthritis: a systematic review and meta-analysis of randomized controlled trials

Y **ong, C Gong, X Peng, X Liu, X Su, X Tao… - Frontiers in …, 2023 - frontiersin.org
Background In recent years, platelet-rich plasma (PRP) injections for osteoarthritis (OA)
have been widely promoted in clinical practice, but their effectiveness is controversial …

Phase II multicenter randomized controlled clinical trial on the efficacy of intra-articular injection of autologous bone marrow mesenchymal stem cells with platelet rich …

JM Lamo-Espinosa, JF Blanco, M Sánchez… - Journal of Translational …, 2020 - Springer
Background Mesenchymal stromal cells are a safe and promising option to treat knee
osteoarthritis as previously demonstrated in different clinical trials. However, their efficacy …

[HTML][HTML] Autologous stem cell therapy in knee osteoarthritis: a systematic review of randomised controlled trials

TGH Wiggers, M Winters… - British Journal of …, 2021 - bjsm.bmj.com
Objective Stem cell therapy is increasingly used for knee osteoarthritis (KOA). We aimed to
review the evidence of autologous mesenchymal stem cell therapy on pain, function and …

Comparative effectiveness of adipose-derived mesenchymal stromal cells in the management of knee osteoarthritis: A meta-analysis

S Muthu, SC Patil, N Jeyaraman… - World journal of …, 2023 - pmc.ncbi.nlm.nih.gov
BACKGROUND Osteoarthritis (OA) is the most common joint disorder, is associated with an
increasing socioeconomic impact owing to the ageing population. AIM To analyze and …