Increasing immunological knowledge and advances in techniques lay the ground for more
efficient and broader application of immunotherapies. gamma delta (γδ) T-cells possess …

Allostery is the most direct and efficient way for regulation of biological macromolecule
function, ranging from the control of metabolic mechanisms to signal transduction pathways …

The potent anti-tumour activities of γδ T cells have prompted the development of protocols in
which γδ-agonists are administered to cancer patients. Encouraging results from small …

Osteonecrosis of the jaw (ONJ) is an uncommon condition noted to occur in patients who are
receiving osteoclast-targeted antiresorptive therapy. The incidence of ONJ in patients taking …

Gamma delta (γδ) Τ cells are non‐conventional T lymphocyte effectors that can interact with
and eradicate tumour cells. Several data demonstrate that these T cells, which are …

Human Vγ2Vδ2 T cells monitor isoprenoid metabolism by recognizing (E)-4-hydroxy-3-
methyl-but-2-enyl pyrophosphate (HMBPP), an intermediate in the 2-C-methyl-d-erythritol-4 …

Bisphosphonates are potent inhibitors of farnesyl pyrophosphate synthase (FPPS) and are
highly efficacious in the treatment of bone diseases such as osteoporosis, Paget's disease …

Dysregulation of isoprenoid biosynthesis is implicated in numerous biochemical disorders
that play a role in the onset and/or progression of age-related diseases, such as …

Cathepsin K (CatK) is essential for osteoclast-mediated bone resorption. CatK expression is
also detected in breast cancer cells that metastasize to bone. Here, the CatK inhibitor L-235 …

A novel catalytic asymmetric Michael addition of azomethine ylide with β-substituted
alkylidene bisphosphates was realized in the presence of a chiral copper (I)/TF-BiphamPhos …