Arginine methylation is an influential post-translational modification occurring on histones,
RNA binding proteins, and many other cellular proteins, affecting their function by altering …

Drug resistance remains a major challenge in cancer treatment, necessitating the
development of novel strategies to overcome it. Protein arginine methyltransferases …

Chromosomal region 9p21 containing tumor suppressors CDKN2A/B and
methylthioadenosine phosphorylase (MTAP) is one of the most frequent genetic deletions in …

Radioresistance is the major reason for the failure of radiotherapy in esophageal squamous
cell carcinoma (ESCC). Previous evidence indicated that stanniocalcin 2 (STC2) participates …

In response to DNA damage, cells have developed a sophisticated signaling pathway,
consisting of DNA damage sensors, transducers, and effectors, to ensure efficient and …

Protein arginine transferase 5 (PRMT5) has been implicated as an important modulator of
tumorigenesis as it promotes tumor cell proliferation, invasion, and metastasis. Studies have …

Posttranslational modification (PTM) of proteins is essential for increasing protein diversity
and maintaining cellular homeostasis, but uncontrolled modification may lead to …

Longevity, functionality, and metabolic fitness are key determinants of chimeric antigen
receptor (CAR) T cell efficacy. Activated T cells follow an ordered differentiation program …

Radioresistance is regarded as the main cause of local recurrence and distant metastasis in
non-small cell lung cancer. However, the underlying mechanisms of radioresistance …

Pancreatic ductal adenocarcinoma (PDAC) is a common malignant tumor of the digestive
tract. Although gemcitabine and other therapeutic agents are effective in patients with …