Epigenetics in human obesity and type 2 diabetes
Epigenetic mechanisms control gene activity and the development of an organism. The
epigenome includes DNA methylation, histone modifications, and RNA-mediated processes …
epigenome includes DNA methylation, histone modifications, and RNA-mediated processes …
Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies
Increased body weight and metabolic disorder including insulin resistance, type 2 diabetes
and cardiovascular complications together constitute metabolic syndrome. The …
and cardiovascular complications together constitute metabolic syndrome. The …
[HTML][HTML] DNA methylation biomarkers in aging and age-related diseases
Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …
alterations in aging and age-related disease. It is currently well established that DNA …
Incretin drugs in diabetic kidney disease: biological mechanisms and clinical evidence
RZ Alicic, EJ Cox, JJ Neumiller, KR Tuttle - Nature Reviews Nephrology, 2021 - nature.com
As the prevalence of diabetes continues to climb, the number of individuals living with
diabetic complications will reach an unprecedented magnitude. The emergence of new …
diabetic complications will reach an unprecedented magnitude. The emergence of new …
Epigenetics of type 2 diabetes mellitus and weight change—a tool for precision medicine?
Pioneering studies performed over the past few decades demonstrate links between
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …
Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin …
Impaired insulin secretion is a hallmark of type 2 diabetes (T2D). Epigenetics may affect
disease susceptibility. To describe the human methylome in pancreatic islets and determine …
disease susceptibility. To describe the human methylome in pancreatic islets and determine …
Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions
M Bensellam, JC Jonas… - Journal of …, 2018 - joe.bioscientifica.com
Like all the cells of an organism, pancreatic β-cells originate from embryonic stem cells
through a complex cellular process termed differentiation. Differentiation involves the …
through a complex cellular process termed differentiation. Differentiation involves the …
Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes
E Nilsson, PA Jansson, A Perfilyev, P Volkov… - Diabetes, 2014 - Am Diabetes Assoc
Genetics, epigenetics, and environment may together affect the susceptibility for type 2
diabetes (T2D). Our aim was to dissect molecular mechanisms underlying T2D using …
diabetes (T2D). Our aim was to dissect molecular mechanisms underlying T2D using …
Genes with epigenetic alterations in human pancreatic islets impact mitochondrial function, insulin secretion, and type 2 diabetes
Epigenetic dysregulation may influence disease progression. Here we explore whether
epigenetic alterations in human pancreatic islets impact insulin secretion and type 2 …
epigenetic alterations in human pancreatic islets impact insulin secretion and type 2 …
Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes
Aging associates with impaired pancreatic islet function and increased type 2 diabetes
(T2D) risk. Here we examine whether age-related epigenetic changes affect human islet …
(T2D) risk. Here we examine whether age-related epigenetic changes affect human islet …