Role of non‐coding variants in cardiovascular disease

K Heshmatzad, N Naderi, M Maleki… - Journal of Cellular …, 2023 - Wiley Online Library
Cardiovascular diseases (CVDs) constitute one of the significant causes of death worldwide.
Different pathological states are linked to CVDs, which despite interventions and treatments …

Loneliness and depression: bidirectional mendelian randomization analyses using data from three large genome-wide association studies

DA Sbarra, FA Ramadan, KW Choi, JL Treur… - Molecular …, 2023 - nature.com
Major depression (MD) is a serious psychiatric illness afflicting nearly 5% of the world's
population. A large correlational literature suggests that loneliness is a prospective risk …

Cardiovascular disease risk in people with severe mental disorders: an update and call for action

L Rødevand, M Tesli… - Current Opinion in …, 2022 - journals.lww.com
The level of CVD comorbidity remains high in SMDs, indicating that most people with SMDs
have not benefitted from recent medical advances. A complex interplay between genetic and …

Shared genetic loci between schizophrenia and white blood cell counts suggest genetically determined systemic immune abnormalities

NE Steen, Z Rahman, A Szabo… - Schizophrenia …, 2023 - academic.oup.com
Background Immune mechanisms are indicated in schizophrenia (SCZ). Recent genome-
wide association studies (GWAS) have identified genetic variants associated with SCZ and …

Psychiatric disorders and subsequent risk of cardiovascular disease: a longitudinal matched cohort study across three countries

Q Shen, DH Mikkelsen, LB Luitva, H Song… - …, 2023 - thelancet.com
Background Several psychiatric disorders have been associated with increased risk of
cardiovascular disease (CVD), however, the role of familial factors and the main disease …

Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes

L Rødevand, S Bahrami, O Frei, Y Chu… - Translational …, 2021 - nature.com
Patients with bipolar disorder (BIP) have a high risk of cardiovascular disease (CVD),
despite considerable individual variation. The mechanisms underlying comorbid CVD in BIP …

Breaking the vicious cycle: The interplay between loneliness, metabolic illness, and mental health

M Ahmed, I Cerda, M Maloof - Frontiers in Psychiatry, 2023 - frontiersin.org
Loneliness, or perceived social isolation, is a leading predictor of all-cause mortality and is
increasingly considered a public health epidemic afflicting significant portions of the general …

Genome-wide analysis of schizophrenia and multiple sclerosis identifies shared genomic loci with mixed direction of effects

M Ahangari, E Everest, TH Nguyen, BC Verrelli… - Brain, Behavior, and …, 2022 - Elsevier
Common genetic variants identified in genome-wide association studies (GWAS) show
varying degrees of genetic pleiotropy across complex human disorders. Clinical studies of …

[HTML][HTML] Prominent health problems, socioeconomic deprivation, and higher brain age in lonely and isolated individuals: A population-based study

AMG de Lange, T Kaufmann, DS Quintana… - Behavioural Brain …, 2021 - Elsevier
Loneliness is linked to increased risk for Alzheimer's disease, but little is known about
factors potentially contributing to adverse brain health in lonely individuals. In this study, we …

Prenatal social support in low-risk pregnancy shapes placental epigenome

M Tesfaye, J Wu, RJ Biedrzycki, KL Grantz, P Joseph… - BMC medicine, 2023 - Springer
Background Poor social support during pregnancy has been linked to inflammation and
adverse pregnancy and childhood health outcomes. Placental epigenetic alterations may …