The autosomal dominantly inherited disorder von Hippel–Lindau disease (VHL) is caused
by germline mutations in the VHL tumour suppressor gene (TSG). VHL mutations …

Summary von Hippel-Lindau disease is a heritable multisystem cancer syndrome that is
associated with a germline mutation of the VHL tumour suppressor gene on the short arm of …

Understanding of molecular mechanisms of tumor growth has an increasing impact on the
development of diagnostics and targeted therapy of human neoplasia. In this review, we …

Abstract von Hippel–Lindau (VHL) disease is an inheritable condition with an incidence of 1
in 36 000 live births. Individuals with VHL develop benign and malignant tumors including …

Object. The goals of this study were to define the natural history and growth pattern of
hemangioblastomas of the central nervous system (CNS) that are associated with von …

Mutations in the von Hippel-Lindau (VHL) gene are responsible for VHL disease, congenital
polycythemia, and are found in many sporadic tumor types as well. Reports of VHL …

The present third edition of the clinical guideline is the result of a thorough revision. The
diagnostic criteria have been changed: There is no longer a distinction between major and …

Object Despite the frequency of cerebellar hemangioblastomas in von Hippel–Lindau (VHL)
disease, their optimum contemporary management has not been defined, and is made …

Introduction Hemangioblastomas are rare, histologically benign, highly vascularized tumors
of the brain, the spinal cord, and the retina, occurring sporadically or associated with the …

von Hippel-Lindau disease (VHL) is an autosomal-dominant neoplasia syndrome that is the
result of a germline mutation of the VHL tumor suppressor gene on the short arm of …