Following fertilization, the two specified gametes must unite to create an entirely new
organism. The genome is initially transcriptionally quiescent, allowing the zygote to be …

Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In
animals, maternal factors contributed by the egg cytoplasm initially control development …

Though cell size varies between different cells and across species, the nuclear-to-
cytoplasmic (N/C) ratio is largely maintained across species and within cell types. A cell …

Due to its specificity, fluorescence microscopy has become a quintessential imaging tool in
cell biology. However, photobleaching, phototoxicity, and related artifacts continue to limit …

All animal embryos pass through a stage during which developmental control is handed
from maternally provided gene products to those synthesized from the zygotic genome. This …

The regulation of transcription requires the coordination of numerous activities on DNA, yet
how transcription factors mediate these activities remains poorly understood. Here, we use …

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …

The awakening of the genome after fertilization is a cornerstone of animal development.
However, the mechanisms that activate the silent genome after fertilization are poorly …

In Drosophila embryogenesis, mitotic control undergoes a significant transition during the
14th interphase. Mitoses before interphase 14 run on maternal products, and occur in …

During embryogenesis, the initial chromatin state is established during a period of rapid
proliferative activity. We have measured with 3-min time resolution how heritable patterns of …