Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets

V Kumar - International immunopharmacology, 2020 - Elsevier
Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …

Beyond traditional coatings: a review on thermal-sprayed functional and smart coatings

D Tejero-Martin, M Rezvani Rad, A McDonald… - Journal of thermal spray …, 2019 - Springer
Thermal spraying has been present for over a century, being greatly refined and optimized
during this time. It has become nowadays a reliable and cost-efficient method to deposit …

The epidemiology of sepsis in Brazilian intensive care units (the Sepsis PREvalence Assessment Database, SPREAD): an observational study

FR Machado, AB Cavalcanti, FA Bozza… - The Lancet infectious …, 2017 - thelancet.com
Background The sepsis burden on acute care services in middle-income countries is a
cause for concern. We estimated incidence, prevalence, and mortality of sepsis in adult …

Vancomycin-resistant enterococcal infections: epidemiology, clinical manifestations, and optimal management

T O'Driscoll, CW Crank - Infection and drug resistance, 2015 - Taylor & Francis
Since its discovery in England and France in 1986, vancomycin-resistant Enterococcus has
increasingly become a major nosocomial pathogen worldwide. Enterococci are prolific …

International Nosocomial Infection Control Consortium report, data summary of 50 countries for 2010-2015: Device-associated module

VD Rosenthal, HM Al-Abdely, AA El-Kholy… - American journal of …, 2016 - Elsevier
Background: We report the results of International Nosocomial Infection Control Consortium
(INICC) surveillance study from January 2010-December 2015 in 703 intensive care units …

[HTML][HTML] The global burden of sepsis and septic shock

L La Via, G Sangiorgio, S Stefani, A Marino, G Nunnari… - Epidemiologia, 2024 - mdpi.com
A dysregulated host response to infection causes organ dysfunction in sepsis and septic
shock, two potentially fatal diseases. They continue to be major worldwide health burdens …

Epidemiology and burden of multidrug-resistant bacterial infection in a develo** country

C Lim, E Takahashi, M Hongsuwan, V Wuthiekanun… - elife, 2016 - elifesciences.org
Little is known about the excess mortality caused by multidrug-resistant (MDR) bacterial
infection in low-and middle-income countries (LMICs). We retrospectively obtained …

Effectiveness of insertion and maintenance bundles to prevent central-line-associated bloodstream infections in critically ill patients of all ages: a systematic review …

E Ista, B Van der Hoven, RF Kornelisse… - The Lancet Infectious …, 2016 - thelancet.com
Background Central-line-associated bloodstream infections (CLABSIs) are a major problem
in intensive care units (ICUs) worldwide. We aimed to quantify the effectiveness of central …

The impact of healthcare-associated infections on mortality in ICU: A prospective study in Asia, Africa, Eastern Europe, Latin America, and the Middle East

VD Rosenthal, R Yin, Y Lu, C Rodrigues… - American journal of …, 2023 - Elsevier
Background The International Nosocomial Infection Control Consortium has found a high
ICU mortality rate. Our aim was to identify all-cause mortality risk factors in ICU-patients …

Sepsis: a roadmap for future research

J Cohen, JL Vincent, NKJ Adhikari… - The Lancet infectious …, 2015 - thelancet.com
Sepsis is a common and lethal syndrome: although outcomes have improved, mortality
remains high. No specific anti-sepsis treatments exist; as such, management of patients …