Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane
immune receptor that is mainly expressed on microglia in the brain and macrophages in the …

Summary β‐site amyloid precursor protein cleaving enzyme‐1 (BACE1) research has
historically focused on its actions as the β‐secretase responsible for the production of β …

Peripheral β-amyloid (Aβ), including those contained in the gut, may contribute to the
formation of Aβ plaques in the brain, and gut microbiota appears to exert an impact on …

A key pathological factor of Alzheimer's disease (AD), the most prevalent form of age-related
dementia in the world, is excessive β-amyloid protein (Aβ) in extracellular aggregation in the …

Biomarkers that predict the clinical onset of Alzheimer's disease (AD) enable the
identification of individuals in the early, preclinical stages of the disease. Detecting AD at this …

In a three-dimensional (3D) representation, each protein molecule displays a specific
pattern of chemical and topological features, which are altered during its misfolding and …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
cognitive impairment and memory loss. Epidemiological evidence suggests that heavy …

Abstract Background The Amyloid theory of Alzheimer's disease (AD) suggests that the
deposition of Amyloid β (Aβ) in the brain triggers a chain of events, involving the deposition …

Alzheimer's disease (AD) is a neurodegenerative disorder. The pathology of AD is
characterized by extracellular amyloid beta (Aβ) plaques, neurofibrillary tangles composed …

Liver-generated plasma apolipoprotein E (apoE) does not enter the brain but nonetheless
correlates with Alzheimer's disease (AD) risk and AD biomarker levels. Carriers of APOE ε4 …