Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research
Human beings are adept at discerning relevant information from complex systems by
processing visual information. Similarly, as scientists labor to understand the fundamental …
processing visual information. Similarly, as scientists labor to understand the fundamental …
Mass spectrometric imaging for biomedical tissue analysis
A mass spectrometer is described as the smallest weighing scale ever used in the world. 1
Mass spectrometry (MS) is a unique technique that has an interdisciplinary nature, which …
Mass spectrometry (MS) is a unique technique that has an interdisciplinary nature, which …
Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach
Abstract See Attems and Jellinger (doi: 10.1093/brain/awx360) for a scientific commentary
on this article. Cognitive changes occurring throughout the pathogenesis of …
on this article. Cognitive changes occurring throughout the pathogenesis of …
Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment
BACKGROUND Spinal muscular atrophy (SMA) is caused by deficient expression of survival
motor neuron (SMN) protein. New SMN-enhancing therapeutics are associated with variable …
motor neuron (SMN) protein. New SMN-enhancing therapeutics are associated with variable …
Altered proteins in the aging brain
We assessed the prevalence of common altered brain proteins in 296 cognitively
unimpaired subjects ranging from age 50 to 102 years. The incidence and the stage of …
unimpaired subjects ranging from age 50 to 102 years. The incidence and the stage of …
Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain
As a means to understand human neuropsychiatric disorders from human brain samples, we
compared the transcription patterns and histological features of postmortem brain to fresh …
compared the transcription patterns and histological features of postmortem brain to fresh …
The sun health research institute brain donation program: description and eexperience, 1987–2007
TG Beach, LI Sue, DG Walker, AE Roher, LF Lue… - Cell and tissue …, 2008 - Springer
Abstract The Brain Donation Program at Sun Health Research Institute has been in
continual operation since 1987, with over 1000 brains banked. The population studied …
continual operation since 1987, with over 1000 brains banked. The population studied …
Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer's disease and track disease progression and cognitive decline
Post-mortem investigations of human Alzheimer's disease (AD) have largely failed to
provide unequivocal evidence in support of the original amyloid cascade hypothesis, which …
provide unequivocal evidence in support of the original amyloid cascade hypothesis, which …
DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain
M Barrachina, I Ferrer - Journal of Neuropathology & …, 2009 - academic.oup.com
DNA methylation occurs predominantly at cytosines that precede guanines in dinucleotide
CpG sites; it is one of the most important mechanisms for epigenetic DNA regulation during …
CpG sites; it is one of the most important mechanisms for epigenetic DNA regulation during …
Brain banks: benefits, limitations and cautions concerning the use of post-mortem brain tissue for molecular studies
Brain banks are facilities providing an interface between generous donation of nervous
tissues and research laboratories devoted to increase our understanding of the diseases of …
tissues and research laboratories devoted to increase our understanding of the diseases of …