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Modulating biomolecular condensates: a novel approach to drug discovery
In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …
been reported to play key roles in many cellular functions by compartmentalizing specific …
Co-transcriptional gene regulation in eukaryotes and prokaryotes
Many steps of RNA processing occur during transcription by RNA polymerases. Co-
transcriptional activities are deemed commonplace in prokaryotes, in which the lack of …
transcriptional activities are deemed commonplace in prokaryotes, in which the lack of …
[HTML][HTML] Functional partitioning of transcriptional regulators by patterned charge blocks
H Lyons, RT Veettil, P Pradhan, C Fornero… - Cell, 2023 - cell.com
Components of transcriptional machinery are selectively partitioned into specific
condensates, often mediated by protein disorder, yet we know little about how this specificity …
condensates, often mediated by protein disorder, yet we know little about how this specificity …
[HTML][HTML] Transcription factors activate genes through the phase-separation capacity of their activation domains
Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding
domains (DBDs) and activation domains (ADs). The DBDs have been well characterized …
domains (DBDs) and activation domains (ADs). The DBDs have been well characterized …
Imaging dynamic and selective low-complexity domain interactions that control gene transcription
INTRODUCTION DNA binding transcription factors (TFs) are quintessential regulators of
eukaryotic gene expression. Early studies of TFs revealed their well-structured DNA binding …
eukaryotic gene expression. Early studies of TFs revealed their well-structured DNA binding …
FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation
RNA modifications regulate a variety of cellular processes including DNA repair. The RNA
methyltransferase TRDMT1 generates methyl-5-cytosine (m5C) on messenger RNA (mRNA) …
methyltransferase TRDMT1 generates methyl-5-cytosine (m5C) on messenger RNA (mRNA) …
UTX condensation underlies its tumour-suppressive activity
UTX (also known as KDM6A) encodes a histone H3K27 demethylase and is an important
tumour suppressor that is frequently mutated in human cancers. However, as the …
tumour suppressor that is frequently mutated in human cancers. However, as the …
An activity-specificity trade-off encoded in human transcription factors
Transcription factors (TFs) control specificity and activity of gene transcription, but whether a
relationship between these two features exists is unclear. Here we provide evidence for an …
relationship between these two features exists is unclear. Here we provide evidence for an …
Formation of chromatin subcompartments by phase separation
Chromatin is partitioned on multiple length scales into subcompartments that differ from
each other with respect to their molecular composition and biological function. It is a key …
each other with respect to their molecular composition and biological function. It is a key …
Heritable transcriptional defects from aberrations of nuclear architecture
Transcriptional heterogeneity due to plasticity of the epigenetic state of chromatin
contributes to tumour evolution, metastasis and drug resistance,–. However, the …
contributes to tumour evolution, metastasis and drug resistance,–. However, the …