Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: integration of the glutamate/GABA-glutamine cycle
Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …
Molecular mechanisms of immunosenescene and inflammaging: relevance to the immunopathogenesis and treatment of multiple sclerosis
O Perdaens, V Van Pesch - Frontiers in neurology, 2022 - frontiersin.org
Aging is characterized, amongst other features, by a complex process of cellular
senescence involving both innate and adaptive immunity, called immunosenescence and …
senescence involving both innate and adaptive immunity, called immunosenescence and …
Counteracting Immunosenescence—Which Therapeutic Strategies Are Promising?
C Hieber, S Grabbe, M Bros - Biomolecules, 2023 - mdpi.com
Aging attenuates the overall responsiveness of the immune system to eradicate pathogens.
The increased production of pro-inflammatory cytokines by innate immune cells under basal …
The increased production of pro-inflammatory cytokines by innate immune cells under basal …
Pollutants in aquatic system: a frontier perspective of emerging threat and strategies to solve the crisis for safe drinking water
Water is an indispensable natural resource and is the most vital substance for the existence
of life on earth. However, due to anthropogenic activities, it is being polluted at an alarming …
of life on earth. However, due to anthropogenic activities, it is being polluted at an alarming …
Impact of aging on animal models of Parkinson's disease
IH Klæstrup, MK Just, KL Holm, AKO Alstrup… - Frontiers in aging …, 2022 - frontiersin.org
Aging is the biggest risk factor for develo** Parkinson's disease (PD), the second most
common neurodegenerative disorder. Several animal models have been developed to …
common neurodegenerative disorder. Several animal models have been developed to …
Mosaic loss of Chromosome Y in aged human microglia
Mosaic loss of Chromosome Y (LOY) is a common acquired structural mutation in the
leukocytes of aging men that is correlated with several age-related diseases, including …
leukocytes of aging men that is correlated with several age-related diseases, including …
Psychological stress as a risk factor for accelerated cellular aging and cognitive decline: The involvement of microglia-neuron crosstalk
The relationship between the central nervous system (CNS) and microglia is lifelong.
Microglia originate in the embryonic yolk sac during development and populate the CNS …
Microglia originate in the embryonic yolk sac during development and populate the CNS …
A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice
Background APOE genotype is the greatest genetic risk factor for sporadic Alzheimer's
disease (AD). APOE4 increases AD risk up to 12-fold compared to APOE3, an effect that is …
disease (AD). APOE4 increases AD risk up to 12-fold compared to APOE3, an effect that is …
Neuroglial senescence, α-synucleinopathy, and the therapeutic potential of senolytics in Parkinson's disease
SJ Miller, CE Campbell, HA Jimenez-Corea… - Frontiers in …, 2022 - frontiersin.org
Parkinson's disease (PD) is the most common movement disorder and the second most
prevalent neurodegenerative disease after Alzheimer's disease. Despite decades of …
prevalent neurodegenerative disease after Alzheimer's disease. Despite decades of …
Age-dependent effects of gut microbiota metabolites on brain resident macrophages
D Hasavci, T Blank - Frontiers in cellular neuroscience, 2022 - frontiersin.org
In recent years, development of age-related diseases, such as Alzheimer's and Parkinson's
disease, as well as other brain disorders, including anxiety, depression, and schizophrenia …
disease, as well as other brain disorders, including anxiety, depression, and schizophrenia …