Cancer metastasis is a biologically complex process that remains a major challenge in the
oncology clinic, accounting for nearly all of the mortality associated with malignant …

Despite recent therapeutic advances in cancer treatment, metastasis remains the principal
cause of cancer death. Recent work has uncovered the unique biology of metastasis …

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. Cancer-associated
fibroblasts (CAFs) are recognized potential therapeutic targets, but poor understanding of …

The response to tumor-initiating inflammatory and genetic insults can vary among
morphologically indistinguishable cells, suggesting as yet uncharacterized roles for …

Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …

Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

A common feature of cancer cells is their ability to rewire their metabolism to sustain the
production of ATP and macromolecules needed for cell growth, division and survival. In …

Advances in our understanding of molecular mechanisms of tumorigenesis have translated
into knowledge-based therapies directed against specific oncogenic signaling targets …

Pancreatic adenocarcinoma presents as a spectrum of a highly aggressive disease in
patients. The basis of this disease heterogeneity has proved difficult to resolve due to poor …

Pioneer transcription factors have the intrinsic biochemical ability to scan partial DNA
sequence motifs that are exposed on the surface of a nucleosome and thus access silent …