DNA methylation in mammalian development and disease
The DNA methylation field has matured from a phase of discovery and genomic
characterization to one seeking deeper functional understanding of how this modification …
characterization to one seeking deeper functional understanding of how this modification …
Evidence that direct inhibition of transcription factor binding is the prevailing mode of gene and repeat repression by DNA methylation
Cytosine methylation efficiently silences CpG-rich regulatory regions of genes and repeats
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …
in mammalian genomes. To what extent this entails direct inhibition of transcription factor …
Methylation across the central dogma in health and diseases: new therapeutic strategies
R Liu, E Zhao, H Yu, C Yuan, MN Abbas… - Signal Transduction and …, 2023 - nature.com
The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …
Single-cell DNA methylation and 3D genome architecture in the human brain
Delineating the gene-regulatory programs underlying complex cell types is fundamental for
understanding brain function in health and disease. Here, we comprehensively examined …
understanding brain function in health and disease. Here, we comprehensively examined …
Single substitution in H3. 3G34 alters DNMT3A recruitment to cause progressive neurodegeneration
Germline histone H3. 3 amino acid substitutions, including H3. 3G34R/V, cause severe
neurodevelopmental syndromes. To understand how these mutations impact brain …
neurodevelopmental syndromes. To understand how these mutations impact brain …
The emergence of the brain non-CpG methylation system in vertebrates
Mammalian brains feature exceptionally high levels of non-CpG DNA methylation alongside
the canonical form of CpG methylation. Non-CpG methylation plays a critical regulatory role …
the canonical form of CpG methylation. Non-CpG methylation plays a critical regulatory role …
MeCP2 is a microsatellite binding protein that protects CA repeats from nucleosome invasion
INTRODUCTION Rett syndrome is a severe neurodevelopmental disorder that is mainly
caused by mutations in the methyl-CpG-binding protein 2 gene (MeCP2). Initially, MeCP2 …
caused by mutations in the methyl-CpG-binding protein 2 gene (MeCP2). Initially, MeCP2 …
MeCP2 is an epigenetic factor that links DNA methylation with brain metabolism
YM Vuu, CT Roberts, M Rastegar - International Journal of Molecular …, 2023 - mdpi.com
DNA methylation, one of the most well-studied epigenetic modifications, is involved in a
wide spectrum of biological processes. Epigenetic mechanisms control cellular morphology …
wide spectrum of biological processes. Epigenetic mechanisms control cellular morphology …
Sex differences in brain disorders
M Ziemka-Nalecz, P Pawelec, K Ziabska… - International Journal of …, 2023 - mdpi.com
A remarkable feature of the brain is its sexual dimorphism. Sexual dimorphism in brain
structure and function is associated with clinical implications documented previously in …
structure and function is associated with clinical implications documented previously in …
Crosstalk among pathways to generate DNA methylome
TK To, T Kakutani - Current Opinion in Plant Biology, 2022 - Elsevier
Cytosine is methylated in both CpG and non-CpG contexts (mCG and mCH, respectively) in
plant genomes. Although mCG and mCH are almost independent in regard to their …
plant genomes. Although mCG and mCH are almost independent in regard to their …