Insertions and deletions: Computational methods, evolutionary dynamics, and biological applications
Insertions and deletions constitute the second most important source of natural genomic
variation. Insertions and deletions make up to 25% of genomic variants in humans and are …
variation. Insertions and deletions make up to 25% of genomic variants in humans and are …
Streamlining and simplification of microbial genome architecture
M Lynch - Annu. Rev. Microbiol., 2006 - annualreviews.org
The genomes of unicellular species, particularly prokaryotes, are greatly reduced in size and
simplified in terms of gene structure relative to those of multicellular eukaryotes. Arguments …
simplified in terms of gene structure relative to those of multicellular eukaryotes. Arguments …
C He, J Holme, J Anthony - Crop breeding: methods and protocols, 2014 - Springer
The KASP genoty** assay utilizes a unique form of competitive allele-specific PCR
combined with a novel, homogeneous, fluorescence-based reporting system for the …
combined with a novel, homogeneous, fluorescence-based reporting system for the …
Performance comparison of exome DNA sequencing technologies
Whole exome sequencing by high-throughput sequencing of target-enriched genomic DNA
(exome-seq) has become common in basic and translational research as a means of …
(exome-seq) has become common in basic and translational research as a means of …
INDELible: a flexible simulator of biological sequence evolution
Many methods exist for reconstructing phylogenies from molecular sequence data, but few
phylogenies are known and can be used to check their efficacy. Simulation remains the most …
phylogenies are known and can be used to check their efficacy. Simulation remains the most …
Bioinformatics challenges for personalized medicine
Motivation: Widespread availability of low-cost, full genome sequencing will introduce new
challenges for bioinformatics. Results: This review outlines recent developments in …
challenges for bioinformatics. Results: This review outlines recent developments in …
Low-coverage sequencing: implications for design of complex trait association studies
New sequencing technologies allow genomic variation to be surveyed in much greater
detail than previously possible. While detailed analysis of a single individual typically …
detail than previously possible. While detailed analysis of a single individual typically …
Millions of years of evolution preserved: a comprehensive catalog of the processed pseudogenes in the human genome
Processed pseudogenes were created by reverse-transcription of mRNAs; they provide
snapshots of ancient genes existing millions of years ago in the genome. To find them in the …
snapshots of ancient genes existing millions of years ago in the genome. To find them in the …
Regulation of ethylene gas biosynthesis by the Arabidopsis ETO1 protein
KLC Wang, H Yoshida, C Lurin, JR Ecker - Nature, 2004 - nature.com
Ethylene gas is used as a hormone by plants, in which it acts as a critical growth regulator.
Its synthesis is also rapidly evoked in response to a variety of biotic and abiotic stresses …
Its synthesis is also rapidly evoked in response to a variety of biotic and abiotic stresses …