Drug combinations: a strategy to extend the life of antibiotics in the 21st century

M Tyers, GD Wright - Nature Reviews Microbiology, 2019 - nature.com
Antimicrobial resistance threatens a resurgence of life-threatening bacterial infections and
the potential demise of many aspects of modern medicine. Despite intensive drug discovery …

Exploiting machine learning for end-to-end drug discovery and development

S Ekins, AC Puhl, KM Zorn, TR Lane, DP Russo… - Nature materials, 2019 - nature.com
A variety of machine learning methods such as naive Bayesian, support vector machines
and more recently deep neural networks are demonstrating their utility for drug discovery …

Machine learning for antimicrobial resistance prediction: current practice, limitations, and clinical perspective

JI Kim, F Maguire, KK Tsang, T Gouliouris… - Clinical microbiology …, 2022 - Am Soc Microbiol
Antimicrobial resistance (AMR) is a global health crisis that poses a great threat to modern
medicine. Effective prevention strategies are urgently required to slow the emergence and …

Alignment-free sequence comparison: benefits, applications, and tools

A Zielezinski, S Vinga, J Almeida, WM Karlowski - Genome biology, 2017 - Springer
Alignment-free sequence analyses have been applied to problems ranging from whole-
genome phylogeny to the classification of protein families, identification of horizontally …

Using Machine Learning To Predict Antimicrobial MICs and Associated Genomic Features for Nontyphoidal Salmonella

M Nguyen, SW Long, PF McDermott… - Journal of clinical …, 2019 - Am Soc Microbiol
Nontyphoidal Salmonella species are the leading bacterial cause of foodborne disease in
the United States. Whole-genome sequences and paired antimicrobial susceptibility data …

Emerging applications of machine learning in food safety

X Deng, S Cao, AL Horn - Annual Review of Food Science and …, 2021 - annualreviews.org
Food safety continues to threaten public health. Machine learning holds potential in
leveraging large, emerging data sets to improve the safety of the food supply and mitigate …

Artificial intelligence and machine learning assisted drug delivery for effective treatment of infectious diseases

S He, LG Leanse, Y Feng - Advanced drug delivery reviews, 2021 - Elsevier
In the era of antimicrobial resistance, the prevalence of multidrug-resistant microorganisms
that resist conventional antibiotic treatment has steadily increased. Thus, it is now …

Develo** an in silico minimum inhibitory concentration panel test for Klebsiella pneumoniae

M Nguyen, T Brettin, SW Long, JM Musser, RJ Olsen… - Scientific reports, 2018 - nature.com
Antimicrobial resistant infections are a serious public health threat worldwide. Whole
genome sequencing approaches to rapidly identify pathogens and predict antibiotic …

Artificial intelligence for antimicrobial resistance prediction: challenges and opportunities towards practical implementation

T Ali, S Ahmed, M Aslam - Antibiotics, 2023 - mdpi.com
Antimicrobial resistance (AMR) is emerging as a potential threat to many lives worldwide. It
is very important to understand and apply effective strategies to counter the impact of AMR …

Interpretable genotype-to-phenotype classifiers with performance guarantees

A Drouin, G Letarte, F Raymond, M Marchand… - Scientific reports, 2019 - nature.com
Understanding the relationship between the genome of a cell and its phenotype is a central
problem in precision medicine. Nonetheless, genotype-to-phenotype prediction comes with …