Schizophrenia is a debilitating psychiatric disorder that affects millions of people worldwide;
however, its etiology is poorly understood at the molecular and neurobiological levels. A …

A characteristic feature of terminal erythropoiesis in mammals is extrusion of the highly
condensed nucleus out of the cytoplasm. Other vertebrates, including fish, reptiles …

Gene regulatory networks (GRNs) are key determinants of cell function and identity and are
dynamically rewired during development and disease. Despite decades of advancement …

Mass spectrometry-based proteomics now enables the absolute quantification of thousands
of proteins in individual cell types. We used this technology to analyze the dynamic …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are progressive
neurodegenerative disorders marked in most cases by the nuclear exclusion and …

Erythroid enucleation, the penultimate step in mammalian erythroid terminal differentiation,
is a unique cellular process by which red blood cells (erythrocytes) remove their nucleus …

Mammalian erythropoiesis involves chromatin condensation that is initiated in the early
stage of terminal differentiation. The mechanisms of chromatin condensation during …

Fine-resolution differentiation trajectories of adult human hematopoietic stem cells (HSCs)
involved in the generation of red cells is critical for understanding dynamic developmental …

Murine-based cellular models have provided and continue to provide many useful insights
into the fundamental mechanisms of erythropoiesis, as well as insights into the …

Histones are classically known to organize the eukaryotic DNA into chromatin. They are one
of the key players in regulating transcriptionally permissive and non-permissive states of the …