Cell adhesion molecules and their roles and regulation in the immune and tumor microenvironment
H Harjunpää, M Llort Asens, C Guenther… - Frontiers in …, 2019 - frontiersin.org
The immune system and cancer have a complex relationship with the immune system
playing a dual role in tumor development. The effector cells of the immune system can …
playing a dual role in tumor development. The effector cells of the immune system can …
E-cadherin: Its dysregulation in carcinogenesis and clinical implications
E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at
adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by …
adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by …
RGD-binding integrins revisited: how recently discovered functions and novel synthetic ligands (re-) shape an ever-evolving field
Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …
investigated as therapeutic targets over the last decades, motivated by their multiple …
Exploring the role of RGD-recognizing integrins in cancer
Integrins are key regulators of communication between cells and with their
microenvironment. Eight members of the integrin superfamily recognize the tripeptide motif …
microenvironment. Eight members of the integrin superfamily recognize the tripeptide motif …
The role of epithelial-to-mesenchymal plasticity in ovarian cancer progression and therapy resistance
Ovarian cancer is the most lethal of all gynecologic malignancies and the eighth leading
cause of cancer-related deaths among women worldwide. The main reasons for this poor …
cause of cancer-related deaths among women worldwide. The main reasons for this poor …
Malignant ascites in ovarian cancer: cellular, acellular, and biophysical determinants of molecular characteristics and therapy response
Simple Summary Accumulation of excess fluid in the abdomen typically indicates abnormal
function or disease, such as cancer, in the underlying tissues. This accumulation of fluid, or …
function or disease, such as cancer, in the underlying tissues. This accumulation of fluid, or …
Heterotypic CAF-tumor spheroids promote early peritoneal metastasis of ovarian cancer
Q Gao, Z Yang, S Xu, X Li, X Yang, P **… - Journal of Experimental …, 2019 - rupress.org
High-grade serous ovarian cancer (HGSOC) is hallmarked by early onset of peritoneal
dissemination, which distinguishes it from low-grade serous ovarian cancer (LGSOC). Here …
dissemination, which distinguishes it from low-grade serous ovarian cancer (LGSOC). Here …
The unique molecular and cellular microenvironment of ovarian cancer
T Worzfeld, E Pogge von Strandmann, M Huber… - Frontiers in …, 2017 - frontiersin.org
The reciprocal interplay of cancer cells and host cells is an indispensable prerequisite for
tumor growth and progression. Cells of both the innate and adaptive immune system, in …
tumor growth and progression. Cells of both the innate and adaptive immune system, in …
[HTML][HTML] Stromal POSTN induced by TGF-β1 facilitates the migration and invasion of ovarian cancer
H Yue, W Li, R Chen, J Wang, X Lu, J Li - Gynecologic oncology, 2021 - Elsevier
Objective Periostin (POSTN) overexpression observed in various cancer types is correlated
with metastasis and tumor progression. However, its effect on the crosstalk between ovarian …
with metastasis and tumor progression. However, its effect on the crosstalk between ovarian …
Osteopontin: a key regulator of tumor progression and immunomodulation
Simple Summary Anti-PD-1/PD-L1 and anti-CTLA-4-based immune checkpoint blockade
(ICB) immunotherapy have recently emerged as a breakthrough in human cancer treatment …
(ICB) immunotherapy have recently emerged as a breakthrough in human cancer treatment …