Plant metabolomics: an indispensable system biology tool for plant science
As genomes of many plant species have been sequenced, demand for functional genomics
has dramatically accelerated the improvement of other omics including metabolomics …
has dramatically accelerated the improvement of other omics including metabolomics …
Genome-wide association studies for common diseases and complex traits
Genetic factors strongly affect susceptibility to common diseases and also influence disease-
related quantitative traits. Identifying the relevant genes has been difficult, in part because …
related quantitative traits. Identifying the relevant genes has been difficult, in part because …
The fine-scale genetic structure of the British population
Fine-scale genetic variation between human populations is interesting as a signature of
historical demographic events and because of its potential for confounding disease studies …
historical demographic events and because of its potential for confounding disease studies …
Using multiple genetic variants as instrumental variables for modifiable risk factors
Mendelian randomisation analyses use genetic variants as instrumental variables (IVs) to
estimate causal effects of modifiable risk factors on disease outcomes. Genetic variants …
estimate causal effects of modifiable risk factors on disease outcomes. Genetic variants …
'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?
G Davey Smith, S Ebrahim - International journal of …, 2003 - academic.oup.com
Associations between modifiable exposures and disease seen in observational
epidemiology are sometimes confounded and thus misleading, despite our best efforts to …
epidemiology are sometimes confounded and thus misleading, despite our best efforts to …
Mendelian randomization: using genes as instruments for making causal inferences in epidemiology
Observational epidemiological studies suffer from many potential biases, from confounding
and from reverse causation, and this limits their ability to robustly identify causal …
and from reverse causation, and this limits their ability to robustly identify causal …
[PDF][PDF] Sample size and statistical power calculation in genetic association studies
A sample size with sufficient statistical power is critical to the success of genetic association
studies to detect causal genes of human complex diseases. Genome-wide association …
studies to detect causal genes of human complex diseases. Genome-wide association …
A genome-wide association study of seed protein and oil content in soybean
Background Association analysis is an alternative to conventional family-based methods to
detect the location of gene (s) or quantitative trait loci (QTL) and provides relatively high …
detect the location of gene (s) or quantitative trait loci (QTL) and provides relatively high …
Linkage disequilibrium map** identifies a 390 kb region associated with CYP2D6 poor drug metabolising activity
LK Hosking, PR Boyd, CF Xu, M Nissum… - The …, 2002 - nature.com
The cytochrome p450 enzyme, CYP2D6, metabolises approximately 20% of marketed
drugs. CYP2D6 multiple variants are associated with altered enzyme activities. Genoty** …
drugs. CYP2D6 multiple variants are associated with altered enzyme activities. Genoty** …
[图书][B] Behavioral genetics
R Plomin - 2008 - books.google.com
Behavioral Genetics, Fifth Edition provides an engaging and clear overview of human and
animal behavioral genetics that is designed to introduce students in the behavioral …
animal behavioral genetics that is designed to introduce students in the behavioral …