Plant metabolomics: an indispensable system biology tool for plant science

J Hong, L Yang, D Zhang, J Shi - International journal of molecular …, 2016 - mdpi.com
As genomes of many plant species have been sequenced, demand for functional genomics
has dramatically accelerated the improvement of other omics including metabolomics …

Genome-wide association studies for common diseases and complex traits

JN Hirschhorn, MJ Daly - Nature reviews genetics, 2005 - nature.com
Genetic factors strongly affect susceptibility to common diseases and also influence disease-
related quantitative traits. Identifying the relevant genes has been difficult, in part because …

The fine-scale genetic structure of the British population

S Leslie, B Winney, G Hellenthal, D Davison… - Nature, 2015 - nature.com
Fine-scale genetic variation between human populations is interesting as a signature of
historical demographic events and because of its potential for confounding disease studies …

Using multiple genetic variants as instrumental variables for modifiable risk factors

TM Palmer, DA Lawlor, RM Harbord… - … methods in medical …, 2012 - journals.sagepub.com
Mendelian randomisation analyses use genetic variants as instrumental variables (IVs) to
estimate causal effects of modifiable risk factors on disease outcomes. Genetic variants …

'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?

G Davey Smith, S Ebrahim - International journal of …, 2003 - academic.oup.com
Associations between modifiable exposures and disease seen in observational
epidemiology are sometimes confounded and thus misleading, despite our best efforts to …

Mendelian randomization: using genes as instruments for making causal inferences in epidemiology

DA Lawlor, RM Harbord, JAC Sterne… - Statistics in …, 2008 - Wiley Online Library
Observational epidemiological studies suffer from many potential biases, from confounding
and from reverse causation, and this limits their ability to robustly identify causal …

[PDF][PDF] Sample size and statistical power calculation in genetic association studies

EP Hong, JW Park - Genomics & informatics, 2012 - synapse.koreamed.org
A sample size with sufficient statistical power is critical to the success of genetic association
studies to detect causal genes of human complex diseases. Genome-wide association …

A genome-wide association study of seed protein and oil content in soybean

EY Hwang, Q Song, G Jia, JE Specht, DL Hyten… - BMC genomics, 2014 - Springer
Background Association analysis is an alternative to conventional family-based methods to
detect the location of gene (s) or quantitative trait loci (QTL) and provides relatively high …

Linkage disequilibrium map** identifies a 390 kb region associated with CYP2D6 poor drug metabolising activity

LK Hosking, PR Boyd, CF Xu, M Nissum… - The …, 2002 - nature.com
The cytochrome p450 enzyme, CYP2D6, metabolises approximately 20% of marketed
drugs. CYP2D6 multiple variants are associated with altered enzyme activities. Genoty** …

[图书][B] Behavioral genetics

R Plomin - 2008 - books.google.com
Behavioral Genetics, Fifth Edition provides an engaging and clear overview of human and
animal behavioral genetics that is designed to introduce students in the behavioral …