Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Many different globular domains bind to the surfaces of cellular membranes, or to specific
phospholipid components in these membranes, and this binding is often tightly regulated …

Plants transport fixed carbon predominantly as sucrose, which is produced in mesophyll
cells and imported into phloem cells for translocation throughout the plant. It is not known …

The yeast cell wall is a strong, but elastic, structure that is essential not only for the
maintenance of cell shape and integrity, but also for progression through the cell cycle …

The yeast cell wall is a highly dynamic structure that is responsible for protecting the cell
from rapid changes in external osmotic potential. The wall is also critical for cell expansion …

The internal organization of eukaryotic cells into functionally specialized, membrane-
delimited organelles of unique composition implies a need for active, regulated lipid …

Polyphosphoinositides (PPIn) are an important family of phospholipids located on the
cytoplasmic leaflet of eukaryotic cell membranes. Collectively, they are critical for the …

The establishment of cell polarity is critical for the development of many organisms and for
the function of many cell types. A large number of studies of diverse organisms from yeast to …

Recent evidence suggesting a strong interplay between components of the renin–
angiotensin system and key mediators of fibrosis led us to hypothesize that renin …

PH (pleckstrin homology) domains represent the 11th most common domain in the human
proteome. They are best known for their ability to bind phosphoinositides with high affinity …