Fatigue as a symptom or comorbidity of neurological diseases

IK Penner, F Paul - Nature Reviews Neurology, 2017 - nature.com
Fatigue, best described as an overwhelming feeling of tiredness and exhaustion, occurs in
the context of various neurological diseases. The high prevalence of fatigue as either a …

Cognitive impairment in multiple sclerosis

ND Chiaravalloti, J DeLuca - The Lancet Neurology, 2008 - thelancet.com
Multiple sclerosis (MS) is a progressive disease of the CNS that is characterised by
widespread lesions in the brain and spinal cord. MS results in motor, cognitive, and …

The impact of fatigue on patients with multiple sclerosis

JD Fisk, A Pontefract, PG Ritvo… - Canadian Journal of …, 1994 - cambridge.org
Although fatigue is recognized as a symptom of MS, there have been insufficient methods for
evaluating this symptom. We administered the Fatigue Impact Scale to 85 MS patients and …

Fatigue in multiple sclerosis: mechanisms, evaluation, and treatment

TJ Braley, RD Chervin - Sleep, 2010 - academic.oup.com
Among patients with multiple sclerosis (MS), fatigue is the most commonly reported
symptom, and one of the most debilitating. Despite its high prevalence and significant …

Fatigue associated with multiple sclerosis: diagnosis, impact and management

R Bakshi - Multiple Sclerosis Journal, 2003 - journals.sagepub.com
In patients with multiple sclerosis (MS) fatigue is the most common symptom and one of the
most disabling features. A s many as 40% have described it as the single most disabling …

Fatigue in multiple sclerosis and its relationship to depression and neurologic disability

R Bakshi, ZA Shaikh, RS Miletich… - Multiple Sclerosis …, 2000 - journals.sagepub.com
We studied multiple sclerosis fatigue (MSF) and its relationship to depression and disability.
Seventy-one patients [50 relapsing-remitting, 21 secondary progressive] were grouped by …

Origin of fatigue in multiple sclerosis: review of the literature

D Kos, E Kerckhofs, G Nagels… - … and neural repair, 2008 - journals.sagepub.com
Fatigue is one of the most common and most disabling symptoms of multiple sclerosis (MS).
Although numerous studies have tried to reveal it, no definite pathogenesis factor behind …

Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial

B Nourbakhsh, N Revirajan, B Morris… - The Lancet …, 2021 - thelancet.com
Background Methylphenidate, modafinil, and amantadine are commonly prescribed
medications for alleviating fatigue in multiple sclerosis; however, the evidence supporting …

Fatigue in multiple sclerosis–insights into evaluation and management

SS Ayache, MA Chalah - Neurophysiologie Clinique/Clinical …, 2017 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the
central nervous system, characterized by the accumulation of numerous neurological …

Apathy: why care?

R Van Reekum, DT Stuss… - The Journal of …, 2005 - Am Neuropsych Assoc
This review presents data showing that apathy is common across a number of disorders.
Apathy is not only common, but is also associated with significant problems: reduced …